SERUM COMPLEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS(SLE)

概要

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Immunological involvement in the pathogenesis of SLE has been suggested by demonstration of LE phenomenon and/or antinuclear antibodies in the serum, fixations of immunoglobullins and β1C-globulin to glomeruli detected by immunofluorescence technique, and fluctuation of the serum complement. Here, serum C'and C'1, and immunune adherence (IA) were estimated in 21 patients with SLE and 18 normals according to the methods of Mayer and Nelson-Nishioka, respectively. Extremely low levels of C'were observed in acute, untreated and clinically severe patients with pyrexia and/or exanthema, positive LE cell preparation, hypergammaglobulinemia, and renal lesion. Clinical remission induced by steroid therapy accompanied elevation of C'. Fluctuation of IA values in lupus patients parallelled well with that of C', while no conclusion could be drawn as to C'1 from the two estimations made in only one patient.
日本アレルギー学会の論文
1968-07-31