Increased Levels of Interleukin-6 in Tracheal Aspirate Fluid Are Indicative of Fetal Inflammation in Ventilated Extremely Low Gestational Age Newborns
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概要
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To determine whether increased serum and/or tracheal aspirate fluid (TAF) levels of IL-6 at birth are associated with fetal inflammation in ventilated extremely low gestational age newborns (ELGAN). METHOD: A total of 36 ELGAN who required mechanical ventilation were enrolled in this study. The patients were classified into two groups: 19 infants who displayed histological evidence of funisitis, which is a marker of fetal inflammation, (funisitis group) and 17 infants without funisitis (comparison group). TAF samples were obtained during routine endotracheal suctioning performed within 2 hours of birth. RESULTS: The funisitis group exhibited significantly higher TAF IL-6 levels than the comparison group (2245 vs. 113 pg/mg total protein; p<0.001). The serum IL-6 levels of the funisitis group were also significantly elevated compared with those of the comparison group (median: 737 vs. 136 pg/mL, p=0.017). Receiver operating characteristic curve analysis of the association between IL-6 levels and the presence of funisitis revealed that the TAF IL-6 concentration had a higher area under the curve (0.947) than the serum IL-6 concentration (0.719). At a cut-off value of 216 pg/mg total protein, the TAF IL-6 level exhibited sensitivity and specificity values of 94.7% and 86.7%, respectively, for detecting funisitis. CONCLUSION: Elevated TAF IL-6 levels at birth are strongly associated with funisitis. The TAF IL-6 concentration is a useful marker for detecting fetal inflammation in ventilated ELGAN.
- 神戸大学の論文
著者
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Sakai Hitomi
Department Of Dermatology National Defence Medical College
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Nakao Hideto
Department Of Neonatology Hyogo Children's Hospital Perinatal Center
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Mizobuchi Masami
Department Of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center
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Tanaka Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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Wada Keiko
Department Of Epidemiology & Preventive Medicine Gifu University Graduate School Of Medicine
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Tanaka Satoshi
Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center
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Fujioka Kazumichi
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Iwatani Sota
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Yoshimoto Seiji
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Mizobuchi Masami
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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