Enhancement of Immunoglobulin M Production in B Cells by the Extract of Red Bell Pepper
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概要
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Under immunocompromised conditions such as aging, cancer, diabetes, burns, and sepsis, external agents may be useful for upregulation of the immune system to prevent infection. Dietary products have the advantage of being safe and easy to take. An extract of red bell pepper (Capsicum annuum L.) flesh markedly enhanced immunoglobulin M (IgM) production by murine B cells and their proliferation. The effect of the extract on IgM production was not abrogated by treatment with polymyxin B and was also observed in spleen cells of lipopolysaccharide-unresponsive C3H/HeJ mice. Treatment of B cells with the extract resulted in an increase in the number of IgM-secreting cells and cluster of differentiation (CD)138-positive cells. The IgM production-enhancing activity was resistant to trypsin treatment but was heat-labile. The activity was eluted in a peak with a molecular weight of 6000 on gel filtration. These results demonstrated that the extract of red bell pepper enhanced IgM production in B cells and suggest that the active substance(s) in the extract is a non-proteinous heat-labile macromolecule.
著者
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TANAKA Satoshi
Department of Physical Science, Osaka Prefecture University
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Tanaka Satoshi
Department Of Nutritional Sciences Faculty Of Nutritional Science Nakamura Gakuen University
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ZHONG Ming
Department of Cardiology, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese
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Zhong Ming
Department Of Cardiology Key Laboratory Of Cardiovascular Remodeling And Function Research Chinese M
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Goto Tomomi
Department of Toxicology, Aichi Prefectural Institute of Public Health
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GOHDA Eiichi
Department of Immunochemistry, Faculty of Pharmaceutical Sciences, Okayama University
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Gohda Eiichi
Department Of Immunochemistry Division Of Pharmaceutical Sciences Okayama University Graduate School
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Sarker Md.
Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate Scho
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Tanaka Satoshi
Department Of Anesthesia Nagano Municipal Hospital
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Tanaka Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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Zhong Ming
Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Sarker Md.
Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Goto Tomomi
Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Goto Tomomi
Department of Electronics, Information and Communication Engineering, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan
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GOHDA Eiichi
Department of Biochemistry, Faculty of Dentistry, Osaka University
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Gohda Eiichi
Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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