E,N-Cadherins and beta-Catenin Expression in Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor
スポンサーリンク
概要
- 論文の詳細を見る
Cadherins are cell-surface glycoproteins that mediate Ca^<2+>-dependent, homophilic cell-cell adhesion. The classical cadherins, E- and N-cadherins, bind to beta-catenin, the lining protein. Dysfunctional expression of these factors seems to be related to tumor invasion and metastasis. This study examined the relationship between changes in E- and N-cadherins, and catenin expression, and biological behavior in medulloblastomas and atypical teratoid/rhabdoid tumors. Specimens of 13 medulloblastomas and two atypical teratoma/rhabdoid tumors were collected and stained immunohistochemically to detect E- and N-cadherins, and beta-catenin. None of the medulloblastomas were immunoreactive for E-cadherin, but both atypical teratoma/rhabdoid tumors were immunoreactive for E-cadherin at the cell-cell borders where epithelial differentiation occurred. In contrast, N-cadherin and beta-catenin were present at the cell-cell borders in 12 of the 13 medulloblastomas and both atypical teratoma/rhabdoid tumors. Nuclear beta-catenin staining was not present in the medulloblastomas or atypical teratoma/rhabdoid tumors. There was no significant difference in the Ki-67 staining index between patients with medulloblastomas showing high and low immunoreactivity for N-cadherin and beta-catenin. Moreover, immunoreactivity for N-cadherin and beta-catenin increased with dissemination in the medulloblastomas. Low immunoreactivity in medulloblastomas tended to be associated with a better prognosis. These results suggest that expression of E-cadherin is useful for the differential diagnosis of atypical teratoma/rhabdoid tumor and medulloblastoma, and the expression of N-cadherin or beta-catenin may be related to the biological behavior of medulloblastomas.
- 日本脳神経外科学会の論文
- 2004-08-15
著者
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OKA Hidehiro
Department of Neurosurgery, Kitasato University School of Medicine
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FUJII Kiyotaka
Departments of Neurosurgery Kitasato University School of Medicine
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Sato Yuichi
Department of Imaging, Health Park Clinic Kurosawa
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TANAKA Satoshi
Department of Physical Science, Osaka Prefecture University
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Tanaka Satoshi
Department Of Nutritional Sciences Faculty Of Nutritional Science Nakamura Gakuen University
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Rutka James
Division Of Neurosurgery The Hospital For Sick Children
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Fujii Kiyotaka
北里大学 医学部脳神経外科
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Fujii Kiyotaka
Kitasato Univ. School Of Medicine
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Sato Yuichi
Department Of Imaging Health Park Clinic Kurosawa
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Oka Hidehiro
Department Of Laboratory Medicine And Pathology Mayo Clinic
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Sagiuchi Takao
Kitasato Univ. School Of Medicine
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UTSUKI Satoshi
Department of Neurosurgery, Kitasato University School of Medicine
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TANIZAKI Yoshinori
Department of Neurosurgery, Kitasato University School of Medicine
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Utsuki S
Department Of Neurosurgery Kitasato University School Of Medicine
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Utsuki Satoshi
Department Of Neurosurgery Kitasato University School Of Medicine
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TSUTIYA Benio
Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences
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KONDO Kouji
Department of Neurosurgery, Kitasato University School of Medicine
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Fujii Kiyotaka
Department Of Brain Sugery School Of Medicine Kitasato University
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Kondo Koji
Department Of Neurosurgery Kitasato University School Of Medicine
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Tsutiya Benio
Department Of Molecular Diagnostics Kitasato University School Of Allied Health Sciences
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Tanizaki Yoshinori
Department Of Neurosurgery Kitasato University School Of Medicine
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Oka Hidehiro
Department Of Neurosurgery School Of Medicine Kitasato University
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Sato Yuichi
Department Of Molecular Diagnosis Graduate School Of Medical Sciences Kitasato University
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Sato Yuichi
Department Of Cardiology Suruga-dai Nihon University Hospital
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Sato Yuichi
Department Of Applied Tumor Pathology Kitasato University Graduate School Of Medical Sciences
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Tanaka Satoshi
Department Of Anesthesia Nagano Municipal Hospital
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Sato Yuichi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Laws Edward
Department Of Neurosurgery University Of Virginia
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Laws Edward
Department Of Neurology And The Neurosurgical Visualization Laboratory And Department Of Neurosurger
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Tanaka Satoshi
Department Of Neurosurgery The Kitasato Institute Medical Center Hospital
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Tanaka Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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