Auditory Alert System for Fluorescence-Guided Resection of Gliomas
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概要
- 論文の詳細を見る
Protoporphyrin IX (PPIX) fluorescence-guided brain tumor resection using 5-aminolevulinic acid labeling is one of the most valuable tools available to determine the extent of glioma infiltration, but requires repeated spectroscopic evaluation of the tissue. The present method informs the surgeon of residual tumor in real time using spectrum analysis of PPIX fluorescence and an audible alert system. The target region was illuminated with a laser with a peak wavelength of 405±1nm in addition to the usual microscope halogen lamp during tumor resection. Analysis of the spectrum detected the PPIX peak using a difference in relative intensity exceeding 500 at 636nm and 632nm, when an audible alert was transmitted to the surgeon. Using this method, infiltration of glioma was detected and confirmed histologically in three of six glioblastomas. The surgeon can detect tumor infiltration far more objectively and with less effort using this system during tumor resection.
- 社団法人 日本脳神経外科学会の論文
- 2008-02-15
著者
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OKA Hidehiro
Department of Neurosurgery, Kitasato University School of Medicine
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SHIMIZU Satoru
Departments of Neurosurgery Kitasato University School of Medicine
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FUJII Kiyotaka
Departments of Neurosurgery Kitasato University School of Medicine
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Shimizu Satoru
Department Of Neurosurgery Kitasato University School Of Medicine
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Oka Hidehiro
Department Of Neurosurgery Kitasato University School Of Medicine
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Fujii Kiyotaka
Department Of Neurosurgery Kitasato University School Of Medicine
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Fujii Kiyotaka
北里大学 医学部脳神経外科
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Fujii Kiyotaka
Kitasato Univ. School Of Medicine
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Oka Hidehiro
Department Of Laboratory Medicine And Pathology Mayo Clinic
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UTSUKI Satoshi
Department of Neurosurgery, Kitasato University School of Medicine
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SUZUKI Sachio
Departments of Neurosurgery
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Utsuki S
Department Of Neurosurgery Kitasato University School Of Medicine
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Utsuki Satoshi
Department Of Neurosurgery Kitasato University School Of Medicine
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MIYASAKA Yoshio
Department of Neurosurgery Kitasato University School of Medicine
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OKA Hidehiro
Neurosurgery
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MIYAJIMA Yoshiteru
Department of Neurosurgery, Kitasato University School of Medicine
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Fujii Kiyotaka
Department Of Brain Sugery School Of Medicine Kitasato University
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Suzuki Sachio
Department Of Neurosurgery Kitasato University School Of Medicine
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Oka Hidehiro
Department Of Neurosurgery School Of Medicine Kitasato University
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Miyajima Yoshiteru
Department Of Neurosurgery Kitasato University School Of Medicine
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Shimizu Satoru
Department Of Neurosurgery Yokohama Stroke And Brain Center
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Yamada Masaru
Department Of Neurosurgery Yamato City Hospital
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Miyasaka Yoshio
Department Of Neurosurgery Yamato Municipal Hospital
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Shimizu Satoru
Department Of Hygiene And Public Health I Tokyo Women's Medical University
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Shimizu Satoru
Kitasato Univ. School Of Medicine Kanagawa Jpn
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Shimizu Satoru
Department Of Biotechnology Faculty Of Engineering Kyoto Sangyo University
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FUJII Kiyotaka
Department of Neurosurgery, Kitasato University School of Medicine
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