Acid-base management affects endothelium-dependent cerebral vasoreactivity in moderately hypothermic rats
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概要
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Objective : The effect on the cerebral circulation of acid-base management under moderate therapeutic hypothermia is not fully understood. We examined cerebral vasoreactivity to topically administered vasodilators and hypercapnia under conditions of normothermia (37℃), induced hypothermia (30℃) with alpha- and pH-stat management, and rewarmed normothermia in rats. Materials and Methods : Using laser-Doppler flowmetry and the closed cranial window method, we measured changes in regional cerebral blood flow (rCBF) and pial arteriole reactivity. rCBF changes during carbon dioxide (CO_2) inhalation, and vasoreactivity to acetylcholine (Ach), an endothelium-dependent vasodilator, sodium nitroprusside (SNP), an endothelium-independent nitric oxide (NO) donor, and cilostazol, a phosphodiesterase III inhibitor were compared in normothermic rats, hypothermic rats subjected to alpha-and pH-stat management, and in rats rewarmed to normothermia. Results : Ach-induced vasodilation was significantly attenuated under alpha-stat- but not pH-stat management and rewarming completely restored the normal vasodilatory response. CO_2 reactivity was preserved under both acid-base management protocols. Conclusion : At moderate hypothermia, endothelium-dependent vasodilation is reversibly impaired under alpha-stat- but not pH-stat conditions, indicating that acid-base management significantly affects endothelial cell function under moderate hypothermia.
- 北里大学の論文
- 2006-09-30
著者
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FUJII Kiyotaka
Departments of Neurosurgery Kitasato University School of Medicine
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Fujii Kiyotaka
Kitasato Univ. School Of Medicine
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YAMADA Masaru
Department of Neurosurgery,Yamato City Hospital
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YUZAWA Izumi
Department of Brain Sugery, School of Medicine, Kitasato University
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Iwamoto Kazuhisa
Department of Neurosurgery, Kitasato University School of Medicine
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Yuzawa I
Department Of Neurosurgery Kitasato University School Of Medicine
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Yuzawa Izumi
Department Of Brain Sugery School Of Medicine Kitasato University
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Yamada Masaru
Department Of Neurosurgery Kitasato University School Of Medicine
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Fujii Kiyotaka
Department Of Brain Sugery School Of Medicine Kitasato University
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Fujii K
Department Of Neurosurgery Kitasato University School Of Medicine
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Miyajima Yoshiteru
北里大学 医学部脳神経外科
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Miyajima Yoshiteru
Department Of Neurosurgery Kitasato University School Of Medicine
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Yamada Masaru
Department Of Neurosurgery Yamato City Hospital
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Yamada Masaru
Department Of Environmental Urban Engineering Faculty Of Engineering Osaka City University
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Iwamoto Kazuhisa
Department Of Neurosurgery Kitasato University School Of Medicine
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Yamada Masaru
Department Of Civil Engineering Osaka City University
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