Molecular biology of histidine decarboxylase and prostaglandin receptors
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概要
- 論文の詳細を見る
Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the molecular mechanisms involved in their synthesis as well as their receptor-mediated responses. We cloned the cDNAs for mouse L-histidine decarboxylase (HDC) and 6 mouse prostanoid receptors (4 PGE2 receptors, PGF receptor, and PGI receptor). We then characterized the expression patterns and functions of these genes. Furthermore, we established gene-targeted mouse strains for HDC and PG receptors to explore the novel pathophysiological roles of histamine and PGs. We have here summarized our research, which should contribute to progress in the molecular biology of HDC and PG receptors.(Communicated by Osamu HAYAISHI, M.J.A.)
- 日本学士院の論文
著者
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TANAKA Satoshi
Department of Physical Science, Osaka Prefecture University
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ICHIKAWA Atsushi
Department of Hematology, Tajimi Prefectural Hospital
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Tanaka Satoshi
Department Of Nutritional Sciences Faculty Of Nutritional Science Nakamura Gakuen University
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SUGIMOTO Yukihiko
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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Ichikawa Atsushi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Sugimoto Yukihiko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Tanaka Satoshi
Department Of Anesthesia Nagano Municipal Hospital
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Tanaka Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tottori University
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