Roles of Prostanoids Revealed From Studies Using Mice Lacking Specific Prostanoid Receptors
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概要
- 論文の詳細を見る
The actions of prostanoids in various physiological and pathophysiological conditions have been being examined using mice lacking different prostanoid receptors.Prostaglandin(PG)I2 worked not only as a mediator of inflammation but also as an antithrombotic agent.PGF2α was found to be an essential inducer of labor.Several important actions of PGE2 are exerted via each of the four PGE2 receptor subtypes:EP1, EP2, EP3 and EP4.PGE2 participated in colon carcinogenesis via the EP1.PGE2 also participates in ovulation and fertilization and contributes to the control of blood pressure under high−salt intake via the EP2.PGE2 worked as a mediator of febrile responses to both endogenous and exogenous pyrogens and as a regulator of bicarbonate secretion induced by acid−stimulation in the duodenum via the EP3.It regulated the closure of ductus arteriosus and showed bone resorbing action via the EP4.PGD2 was found to be a mediator of allergic asthma.These studies have revealed important roles of prostanoids, some of which had not previously been known.
- 社団法人 日本薬理学会の論文
- 2000-08-01
著者
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Ushikubi Fumitaka
Department of Pharmacology, Asahikawa Medical College
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Ushikubi Fumitaka
Department Of Pharmacology Asahikawa Medical College
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Ushikubi Fumitaka
福島県立医科大学 内科学第3
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Narumiya Shuh
Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
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ICHIKAWA Atsushi
Department of Hematology, Tajimi Prefectural Hospital
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Narumiya S
京都大学 医学研究科神経･細胞薬理学教室
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SUGIMOTO Yukihiko
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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Narumiya Shuh
Department Of Surgery Kitasato University
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Narumiya Shuh
Department Of Pharmacology Faculty Of Medicine Kyoto University
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Ichikawa Atsushi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Sugimoto Yukihiko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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