APHIDICOLIN: A SPECIFIC INHIBITOR OF DNA SYNTHESIS IN SYNCHRONOUS MASTOCYTOMA P-815 CELLS
スポンサーリンク
概要
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The influence of aphidicolin on cell multiplication and DNA synthesis was examined using synchronous mouse mastocytoma P-815 cells. Aphidicolin was cytotoxic specifically to the cells of the S phase of the cell cycle. This cytotoxicity was reversed by appropriately washing the drug-treated cells, but not by the addition of deoxyribonucleosides. Aphidicolin, a potent inhibitor of DNA synthesis, selectively inhibited the activity of partially purified DNA polymerase α from the nucleus and the cytosol of mastocytoma cells, but did not affect the activity of DNA polymerase β. Furthermore, aphidicolin had no effect on the synthesis of RNA and protein, and produced no changes in cell size at least for one generation.
- 社団法人 日本薬理学会の論文
著者
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ICHIKAWA Atsushi
Department of Hematology, Tajimi Prefectural Hospital
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IKEGAMI Susumu
Department of Applied Biochemistry, Faculty of Applied Biological Sciences, Hiroshima University
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Ikegami Susumu
Department Of Applied Biochemistry Faculty Of Applied Biological Science
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Ichikawa A
Kyoto Univ. Kyoto Jpn
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Ichikawa Atsushi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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NEGISHI Manabu
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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TOMITA KENKICHI
Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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Negishi Manabu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Tomita Kenkichi
Department Of Health Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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IKEGAMI Susumu
Department of Agricultural Chemistry, University of Tokyo
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