Inhibition of Multiplication of Mouse Carcinoma FM3A Cells by Methotrexate Encapsulated in Liposomes That Contain Hematoporphyrin Derivative in the Membrane
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概要
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Approximately 0.14μmol of hematoporphyrin derivative (a preparation made by treating hematoporphyrin with sulfuric acid-acetic acid) per μmol of phospholipids was included in the lipid phase of reverse-phase evaporated liposomes which were composed of 4 μmol of phosphatidylcholine, 1 μmol of phosphatidylglycerol, 5 μmol of cholesterol and 1 μmol of α-tocopherol. Treatment of mouse carcinoma FM3A cells with liposomes of the above composition which encapsulated 25 mM methotrexate, a water-soluble antifolate drug, inhibited cell multiplication completely whereas the same amount of the drug encapsulate in liposomes that were devoid of hematoporphyrin derivative and α-tocopherol did not affect cell growth. Of the constituents of the hematoporphyrin derivative, O, O-diacetylhematoporphyrin was the most effective in raising the efficacy of delivery of aqueous materials into FM3A cells.
- 社団法人 日本農芸化学会の論文
著者
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IKEGAMI Susumu
Department of Agricultural Chemistry, University of Tokyo
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MORI Kunizo
Department of Applied Biochemistry, Hiroshima University
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IMAYOSHI Junji
Department of Applied Biochemistry, Hiroshima University
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