Inhibitory effect of tritoqaline (TRQ) on histamine release from mast cells.
スポンサーリンク
概要
- 論文の詳細を見る
Tritoqualine (TRO), used clinically as an antiallergic drug, did not inhibit histidine decarboxylase activity (HDC, EC. 4.1.1.22.) partially purified from fetal rats and the enzymes prepared from mastocytoma P-815 cells. However, TRQ inhibited the histamine release from rat peritoneal mast cells induced by compound 48/80 and ATP. TRQ was also effective in inhibiting antigen-induced histamine release in rat mast cells sensitized actively or passively by the homologous antiDNP-Ascaris antibody. Preincubation of cultured mastocytoma P-815 cells in a medium including TRQ inhibited non-cytotoxically the histamine release of mastocytoma cells induced by compound 48/80, and the effect of TRQ became more marked with lengthening of the culture period in the presence of TRQ. It was concluded from these results that one of the main actions of TRO as an antiallergic drug was not the inhibitory action on HDC, but might be ascribed to its inhibitory effect on histamine release from mast cells.
著者
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Ichikawa Atsushi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kyoto University
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YUASA Satoshi
Biosciences Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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YUASA Satoshi
Bioscience Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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UMEZU Kohei
Biosciences Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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SUDOH Atsuko
Biosciences Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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KIKUMOTO Ryoji
Biosciences Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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SUDOH Atsuko
Bioscience Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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UMEZU Kohei
Bioscience Laboratory, Research Center, Mitsubishi Chemical Ind. Ltd.
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