N-terminal Pro-brain Natriuretic Peptide Levels in Dichorionic Diamniotic Twins with Selective Intrauterine Growth Restriction
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概要
- 論文の詳細を見る
Monochorionic diamniotic (MD) twins with selective intrauterine growth restriction (sIUGR) have known associations with cardiac complications. However, the cardiac load of dichorionic diamniotic (DD) twins with sIUGR (DD-sIUGR) remains unclear. N-terminal pro-brain natriuretic peptide (NT-pro BNP) is a convenient marker of cardiac dysfunction in neonates, and is elevated in MD twins with sIUGR (MD-sIUGR). However, there are no reports assessing serum NT-pro BNP levels in DD-sIUGR. Here, we aimed to clarify serum NT-pro BNP levels at birth in DD-sIUGR, and to compare them with those of MD-sIUGR. Forty-one DD twin pairs admitted to our center between October 2007 and January 2013 were enrolled in this study and separated into two groups: nine twins with sIUGR (DD-sIUGR group) and 32 twins without sIUGR (DD without sIUGR group). Sixteen MD twins with sIUGR (MD-sIUGR group) served as positive controls. Serum NT-pro BNP levels at birth in DD-sIUGR [median 2,115 pg/ml (range, 443–6,590 pg/ml)] were significantly higher than in DD without sIUGR [1,080 pg/ml (range, 313–3,470 pg/ml); p=0.001], and significantly lower than in MD twins with sIUGR [4,520 pg/ml (range, 529–62,400 pg/ml); p=0.04]. Serum NT-pro BNP levels between larger and smaller DD co-twins were significantly correlated (r = 0.582; p<0.0001). In conclusion, serum NT-pro BNP levels at birth in DD twins with sIUGR were higher than those without, and lower than in MD twins with sIUGR.
- 神戸大学の論文
著者
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Sakai Hitomi
Department Of Dermatology National Defence Medical College
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Nakao Hideto
Department Of Neonatology Hyogo Children's Hospital Perinatal Center
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Mizobuchi Masami
Department Of Neonatology Hyogo Prefectural Kobe Children's Hospital Perinatal Center
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Wada Keiko
Department Of Epidemiology & Preventive Medicine Gifu University Graduate School Of Medicine
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Iwatani Sota
Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center
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Yoshimoto Seiji
Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center
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Fujioka Kazumichi
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Sakai Hitomi
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Iwatani Sota
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Nakao Hideto
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Yoshimoto Seiji
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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Mizobuchi Masami
Department of Neonatology Hyogo Prefectural Kobe Children's Hospital
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