A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis

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概要

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• A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.

著者

• Sakai Hitomi

  Department Of Dermatology National Defence Medical College

• Sakuraba Haruhiko

  Department Of Agricultural Chemistry University Of Osaka Prefecture

• Nakagawa Hideyuki

  Department Of Pharmacology Osaka Dental University

• NAGASAKA Kuniko

  Fukae Nagasaka Clinic

• EDO Kozue

  Department of Environmental Symbiosis, Institute of Socio-Arts and Sciences, The University of Tokus

• Shinohara Mitsuko

  Depatment of Pharmacology, Osaka Dental University, Japan

• Nakagawa Hideyuki

  Depatment of Pharmacology, Osaka Dental University, Japan

• Kato Koji

  Depatment of Pharmacology, Osaka Dental University, Japan

• Iwaki Futoshi

  Depatment of Pharmacology, Osaka Dental University, Japan

• Ohura Kiyoshi

  Depatment of Pharmacology, Osaka Dental University, Japan

• Edo Kozue

  Department Of Environmental Symbiosis Institute Of Socio-arts And Sciences The University Of Tokushi

• Nakagawa Hideyuki

  Department Of Pharmacology Osaka Dental University:department Of Environmental Symbiosis Institute O

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