柴胡桂枝湯の神経薬理学的研究(第2報)

概要

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In the previous study, the Chinese herbal drug "Saiko-Keishi-To" (SK) showed an inhibitory effect on the pentylenetetrazol (PTZ) induced characteristic phasic depolarization of the intracellular potential of the snail's neuron. In this report, we studied the neuropharmacological effect of SK on the mammalian central nervous system as well as the effect of this herbal drug on the experimental animal model for epilepsy. In ddy strain mice, a dose of 4 g/kg per os of SK showed a slight prolongation of sleeping time produced by hexobarbital, but no effect on body temperature. Electroencephalographic activity in rabbits showed no obvious change by oral administration of SK. In ddy strain mice, no inhibitory effect was observed on tonic and clonic seizure induced by electrical shock, strychnine or PTZ. The continuous oral administration of SK for 14 days at a dose of 4 g/kg showed a statistically significant inhibitory effect on the audiogenic seizure of innately highly susceptible DBA mice, but no remarkable inhibitory effect was observed on the kindling effect in Wister strain rats. These results demonstrate that SK has no anticonvulsant effect in examinations using conventional pharmacological screening methods, but has a certain inhibitory effect on innately susceptible mice seizure.
日本生薬学会の論文
1976-12-20