生薬ならびに植物成分の薬理学的研究(第1報)日本産吉草根の薬理作用
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概要
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Some pharmacological actions of kessoglycol diacetate (KGD) and dichloromethane extract (VRD) obtained from Valeriana fauriei var. fauriei were examined. The sleeping time after hexobarbital sodium was prolonged by preadministration of KGD or VRD in mice. Spontaneous motor activity as judged by an open field test was slightly decreased by VRD in terms of the rearing frequency while it was markedly decreased by KGD in terms of both the ambulation and rearing frequency in mice. Hypothermic action and antielectroshock convulsant action were not shown in mice with KGD or VRD. Passive avoidance response was inhibited in mice by both KGD and VRD. Emotional excretion (defecation and urination) was also suppressed by both of them. Aggressiveness of the isolated mice was inhibited by a single administration of KGD or VRD. Furthermore, the degree of inhibition was gradually increased with repeated daily treatment with VRD for 13 days. A similar but weaker inhibition was observed by repeated daily administration of KGD. Based on these findings, it may be concluded that both KGD and VRD have sedative action.
- 公益社団法人日本薬学会の論文
- 1973-05-25
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