柴胡桂枝湯の神経薬理学的研究(第1報)

概要

論文の詳細を見る
The Chinese herbal drug "Saiko-Keishi-To" has been used as an antiepileptic agent by Dr. Saburo Aimi according to the indications in the ancient Chinese medical books "Sho-kanron" and "Kinkiyoryaku". He obtained the remarkable results in the complete cure of the various types of epilepsy. We examined the effect of this "Saiko-Keishi-To" from the viewpoint of experimental neuropharmacology. As a model of epilepsy at the level of a single neuron. We used the pentylenetetrazol (PTZ)-induced characteristic intracellular potential change of the giant nerve cell of the snail (Euhadra peliomphala) which closely resembles the intracellular potential change of the neuron in the cerebral cortex of the cat during seizure discharge caused by various procedures. The 2% solution of the vacuum-concentrated and liophilized extract of "Saiko-Keishi-To" has a complete inhibitory effect on PTZ-induced phasic depolarization. The 2% solutions of the lyophilized extract of Bupleuri Radix, Paeoniae Radix, Cinnamomi Cortex and Zingiberis Rhizoma which are the components of "Saiko-Keishi-To" also have almost the same effect. These results indicate that "Saiko-Keishi-To" has an anticonvulsant effect at the level of the single isolated neuron.
日本生薬学会の論文
1975-12-20