竜骨および牡蛎の薬理作用

概要

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We examined the effects of Longgu and Oyster Shell on the nervous system, which have long been considered as sedative drugs in the Kampo medicine. 1) By continuous oral administration, Longgu elevated the body temperature of mice, inhibited the locomotion activity of rats and decreased the frequency of convulsions in El mice by tossing-up procedures. It also showed a local anesthetic action in excised ischiadicus nerve of frogs. The effect was 0.37 when the effect of 0.5% procaine was taken as 1. 2) By continuous oral administration, Oyster Shell showed inhibition of locomotion activity, prolongation of latency time for tonic convulsions induced by pentylenetetrazol in mice, and a decrease in frequency of convulsions by tossing-up procedures in El mice. It also showed local anesthetic action in excised ischiadicus nerve of the frog. The effect was 0.92 when the effect of 0.5% procaine was taken as 1. 3) The mixed prescription, Saiko-ka-ryukotsu-borei-to, from which both Longgu and Oyster Shell had been removed had weakly effects on the nervous system such as prolongation of sleeping time, lowering action of body temperature and anticonvulsive effect.
日本生薬学会の論文
1998-08-20