T0201-3-5 低コヒーレンス干渉信号における光学特徴量を用いた動脈硬化組織性状推定法の検討([T0201-3]細胞の構造と流れにおけるマイクロ・ナノスケール解析(3))

概要

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In few decades, with the increase of a cardiovascular disease, e.g. acute coronary syndromes. Unstable plaques predisposed to rupture, causing acute coronary syndromes, are characterized by thin fibrous cap covering a large lipid core. Therefore, a non-invasively diagnosing system of tissue properties with micrometer scale has been crucially promising to detect vulnerability of cardiovascular disease. In this study, "Attenuation. Reflection and Variance OCT" (ARV-OCT) is proposed as a tomographically visualizing technique of tissue characterization. This is based on spatial fields of scattering attenuation, reflection and variance in an OCT image. ARV-OCT was ex vivo applied to atherosclerotic plaques of rabbits. As a result, three parameters were separately correlated fibrous and lipid comparing with histological images. Consequently, the present method has a highly diagnosing potential of tissue characterization of atheroscherotic plaques.
一般社団法人日本機械学会の論文
2010-09-04