2-Color Optical Coherence Dosigraphyを用いた粥状硬化不安定プラークにおける脆弱性マイクロ断層診断法(流体工学,流体機械)

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Recently, optical coherence tomography (OCT) has been being applied to cardiovascular medical diagnosis as a tomographic visualizing technique of unstable atherosclerotic plaque with high resolution of 1 to 10 micrometer. Nevertheless, the vulnerability associated with macrophage invasion into atherosclerotic plaque can never be in vivo detected by any diagnostic approach. Previously, we proposed 2-Color Optical Coherence Dosigraphy (2C-OCD), which can provide microscale tomographic images of drug infiltration. In this study, the vulnerability diagnosing technique of unstable plaque is proposed, by means of 2C-OCD using selective uptake of PDD photosensitizer to lipidrich plaque and macrophage. In order to evaluate the bio-availability, 2C-OCD was ex vivo applied to aorta segments of rabbits with photosensitizer AlPcS administered, comparing between drug infiltration obtained by 2C-OCD and their histological images. Consequently, drug infiltration was only observed to increase significantly at plaque lesion where photosensitizer's fluorescence could be captured. Additionally, AlPcS accumulation appeared to be similar to macrophage invasion visualized by immuno-staining. Therefore, it was confirmed that 2C-OCD could diagnose specific tissue characteristics of unstable plaque as well as the vulnerability attributed to macrophage invasion, based on the obtained drug infiltration.
社団法人日本機械学会の論文
2009-12-25

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