2色低コヒーレンス光干渉計を用いたDrug Delivery Systemの定量画像評価法(流体工学,流体機械)

概要

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Recently, clinical treatments applying drug delivery system (DDS), e.g. photo-dynamic therapy, have been being developed. However, it is quite difficult to in vivo dianose spatiotemporal distribution of drug infiltration, so the validation study should be too insufficient to progress the DDS development. In this study, we propose a quantitatively visualizing assay of DDS, namely 2-Color Optical Coherence Dosigraphy (2C-OCD), which is based on optical coherence tomography using two waveband light sources having different optical absorbance of drug. This can simultaneously provide microscale tomographic images of scatterer density and drug concentration. In order to confirm 2C-OCD, two buffer solutions having different concentration combination of Intralipid and DDS drug were pressurized from respective ends of Y-shaped microchannel. Their concentration maps were calculated at the cross-section of Y-junction using 2C-OCD. Consequently, the results agreed with inlet conditions of concentration combination, thus 2C-OCD can visualize drug concentration with spatial resolution 5μm×10μm and accuracy±11.3μM.
社団法人日本機械学会の論文
2008-07-25