2823 低コヒーレンス干渉画像による生体組織歪み分布計測法の定量評価(J08-2 バイオメカニクス,J08 生体・環境適合材料の創製・強度評価技術開発)

概要

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Acute coronary syndromes, e.g. myocardial infarctions, are caused by the rupture of unstable plaques on coronary arteries. The stability of plaque, which depends on bio-mechanical properties of fibrous cap, should be diagnosed crucially. Recently, Optical Coherence Tomography (OCT) has been developed as a cross-sectional imaging method of biological tissue with high resolution, i.e. 1〜10μm. It is, however, difficult to estimate biomechanical characteristics, e.g. instability of plaque, because OCT images have just speckle patterns by back-scattering from tissue. We proposed Optical Coherence Straingraphy (OCS), e.g. an estimator of micro bio-strain distribution, has been being improved on the basis of Optical Coherence Tomography. This is composed of the recursive cross-correlation technique, Adjacent Cross-correlation Multiplication (ACM) as a speckle noise reduction method and displacement vector correction which can take account of tissue uncompressibility. Thus this can provide an accurate strain map with high resolution. In this study, this was applied to simulated OCT images of compressed tissue samples to carry out the accuracy verifications. Consequently, it was quantitatively confirmed that the proposed method can obtain the accurate strain map with high resolution.
社団法人日本機械学会の論文
2007-09-07