MNM-1A-5 低コヒーレンス干渉計を用いた生体組織におけるマイクロメカニクスの3次元断層可視化法の検討(セッション 1A マイクロ・ナノスケールバイオ計測と医用応用)

概要

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3-Dimensional Optical Coherence Straingraphy (3D-OCSA) has been developed as a 3-dimensionally tomographic and non-invasive visualizing technique of micro strain distribution. 3D-OCSA can provide the accurate 3-dimensional displacement vector distribution, by recursively applying the speckle cross-correlation method based on Fast Fourier Transformation as well as the high-accurate subpixel analysis, i.e. upwind gradient method. Finally, the spatial distribution of 3-dimensional strain tensor can be locally and robustly extracted even from complicated OCT interference signals by means of the weighted moving least square method. 3D-OCSA was applied to phantom OCT images based on numerical simulation for deformation analysis and then Monte Carlo simulation for OCT scattering intensity profile, so as to carry out the accuracy verifications. As a result, it was confirmed that 3-domensionally tomographic strain distribution calculated by 3D-OCSA agreed quantitatively with the simulated one at the resolution of micro scale.
一般社団法人日本機械学会の論文
2010-10-12