1615 2色低コヒーレンス光断層画像を用いたドラッグデリバリーシステム定量評価法の検討(S22 ドラッグデリバリーシステムと流体力学,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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Recently, clinical treatments applying drug delivery system (DDS), e.g. Drug Eluting Stent, have been being developed. However, it is quite difficult to in vivo diagnose spatiotemporal distribution of drug infiltration, so the validation study should be too insufficient to progress the DDS development. In this study, we proposed a quantitatively visualizing assay of DDS, namely 2-Color Optical Coherence Dosigraphy (2C-OCD), which was based on optical coherence tomography using two waveband light sources having different optical absorbance of drug. This can simultaneously provide microscale tomographic images of scatterer density and drug concentration. In this paper, 2C-OCD was applied to biomedical tissue administered DDS drug (AlPcS). The aortic vessel of rabbit, which had highcholesterol diet, was used, and absorption distribution was calculated at the area of arterial plaque. Consequently, tissue characterization and drug distribution in biomedical tissue could be detected by 2C-OCD.
社団法人日本機械学会の論文
2008-08-02