1130 低コヒーレンス光を用いた生体組織弾性率分布計測法の研究(S11-2 計測と力学-生体への応用(2),S11 計測と力学-生体への応用)

概要

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Most myocardial infarctions and other acute coronary syndromes are caused by rupture of unstable plaques in the coronary arteries. The intravascular ultrasonic (IVUS) has been generally used for discovery of unstable plaques. Since the spatial resolution of IVUS is about 100 micro m, an unstable plaque can not be determined. Recently, Optical Coherence Tomography (OCT) has been developed as a method of obtaining cross-sectional images of microstructural biological tissue with high resolution, i.e. 1〜10 micro m. Even though using OCT, it is difficult to estimate biomechanical characteristics to diagnose an unstable plaque, because OCT images have just speckle patterns of scattering light from tissue. In this study, presented is Optical Coherence Elastography (OCE) modified by OCT, which can diagnose tissue elasticity distribution. This is based on the recursive cross-correlation method, resulting in deformation vector distribution with high resolution, In addition, the local vector interpolation by least square method is introduced to remove erroneous vectors and smooth vector distribution. This was experimentally applied to compressed isotropic samples. Consequently, uniform strain distribution was obtained to comparison with the conventional cross-correlation method, thus the proposed method was validated.
社団法人日本機械学会の論文
2005-09-18