753 ラテックス擬似血管を用いたOptical Coherence Straingraphyの実験的検証(S01-3 細胞と組織のバイオメカニクス(3)-ミクロからマクロまで-,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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OCT is intrinsically difficult to estimate biomedical characteristics of tissue, because OCT images just show speckle patterns originated from back-scattering light from tissue. Authors proposed Optical Coherence Straingraphy (OCS), which could visualize tissue mechanical information, e.g. strain distribution, from OCT speckle deformation. OCS is based on Recursive Cross-correlation technique, resulting in provide displacement vector distribution with high resolution. Furthermore, Adjacent Cross correlation Multiplication is introduced as a speckle noise reduction method. Finally, Strain distribution was calculated using Weighted Moving Least Square Method to suppress the differential error from detection noise. However, it has not been experimentally verified exhaustively. In this study, experimental verification study on OCS was carried out using artificial blood vessels. In the experiment, and OCS detected tomographic strain distribution in the phantom bended by an indenter. Strain distribution was compared to numerically simulated results based on Finite Element Method. Consequently, both results are analogous in terms of strain pattern. It was confirmed that OCS could be effective to an assessment of atherio sclerosis, micro mechanical biopsy.
社団法人日本機械学会の論文
2008-08-02