S0201-1-5 動脈硬化血管を用いたOptical Coherence Straingraphyの検証研究(マイクロ・ナノバイオメカニクス:細胞生物学への接近(1)解析と応用)

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The rupture of unstable plaques on coronary artery should cause acute coronary syndromes. Authors proposed Optical Coherence Straingraphy (OCS), which could visualize cross-sectional strain distribution of tissue from speckle images obtained by Optical Coherence Tomography (OCT). This method is constructed by Recursive Cross-correlation (RC) technique and Weighted Moving Least Square Method (WMLSM), which can provide tomographic strain distribution of tissue with high resolution. In this study, the verification study was carried out using atherosclerotic plaques of WHHL rabbit. Strain distributions calculated by OCS were verified by means of simulated results based on histological images. Consequently, OCS results agreed qualitatively with simulated ones. RMS error △_<εzz>= ±0.845 × 10^<-3> was calculated from spatially distributed strain data, which amounted to 33.8% for the maximum strain by OCS. Thus, the proposed method can detect tomographic strain distribution at the micro scale resolution. It was concluded that OCS could provide clinical information of atherosclerotic plaques as "Micro Mechanical Biopsy".
社団法人日本機械学会の論文
2009-09-12

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