J0406-1-2 ナノ構造物の共振計測と超高感度バイオセンサへの応用(超音波計測・解析法の新展開(1))

概要

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We developed the picosecond ultrasound spectroscopy for measuring mechanical resonance frequencies of sub-terahertz frequencies in nanostructures, including ultrathin films and nanowires. It uses the pump-probe technique with ultrafast light pulses for generation and detection of picosecond ultrasound vibrations. The mechanical responses are applied to the detection of proteins in liquid through the antigen-antibody reaction. 20 nm Pt thin films and 100 nm SiN thin films were used as the oscillators. Staphylococcus aureus protein A and anti-human immunoglobulin G (hIgG) antibody were used as the receptor proteins and they were immobilized on the oscillator surfaces. hIgG molecules were then detected in the homebuilt flow injections system.
社団法人日本機械学会の論文
2009-09-12