Anti-inflammatory and Analgesic Activities of Edgeworthia chrysantha and Its Effective Chemical Constituents(Pharmacognosy)
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概要
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The barks and roots of Edgeworthia chrysantha LINDL., which have been used as the folk medicine "Zhu shima" in southern China due to their detumescence and acesodyne effects, were investigated for their anti-inflammatory and analgesic activities using a xylene-induced ear edema assay in mice and Freund's complete adjuvant-induced paw edema as inflammation models, and the acetic acid-induced writhing test as an analgesic model. Fractions effective in terms of anti-inflammatory and analgesic activities were obtained from E. chrysantha. The chloroform-soluble fraction (CHF) showed significant anti-inflammatory (p<0.01-0.001) and analgesic (p<0.01) effects. On further purification by silica gel, three major coumarins, edgeworin (EdN), edgeworosides A and C (EdeA and EdeC), were isolated from the chloroform fraction and both anti-inflammatory and analgesic activities were evaluated. EdN and EdeA had anti-inflammatory (p<0.05-0.01) and analgesic (p<0.001) effects, while EdeC only showed an analgesic effect. The results of this study thus demonstrated that the coumarins EdN, EdeA and EdeC in this plant may be active constituents that contribute to the anti-inflammatory and analgesic effects.
- 2008-09-01
著者
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Zhang Wei-Dong
School of Pharmacy, Shanghai Jiao Tong University
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ZHANG Wei
Department of Health Toxicology, School of Radiation Medicine and Public Health, Soochow University,
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SU Juan
Department of Phytochemistry, School of Pharmacy, Second Military Medical University
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ZHANG Chuan
Department of Phytochemistry, School of Pharmacy, Second Military Medical University
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Zhang Wei-dong
Department Of Phytochemistry School Of Pharmacy Second Military Medical University:school Of Pharmac
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Su Juan
Department Of Phytochemistry School Of Pharmacy Second Military Medical University
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Zhang Chuan
Department Of Phytochemistry School Of Pharmacy Second Military Medical University
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Zhang Chuan
Department Of Neurosurgery Pet Ct Center Tianjin Medical University General Hospital
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HU Xiao-Jia
School of Pharmacy, Shanghai Jiaotong University
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JIN Hui-Zi
School of Pharmacy, Shanghai Jiaotong University
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XU Wen-Zheng
School of Pharmacy, Shanghai Jiaotong University
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CHEN Ming
School of Pharmacy, Shanghai Jiaotong University
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LIU Xiao-Hua
Department of Phytochemistry, Second Military Medical University
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Zhang Wei-dong
School Of Pharmacy Shanghai Jiao Tong Univ.
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Liu Xiao-hua
Department Of Phytochemistry Second Military Medical University
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Zhang Wei
Department Of Cardiology Key Laboratory Of Cardiovascular Remodeling And Function Research Chinese M
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Xu Wen-zheng
School Of Pharmacy Shanghai Jiaotong University
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Jin Hui-zi
School Of Pharmacy Shanghai Jiaotong University
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Hu Xiao-jia
School Of Pharmacy Shanghai Jiaotong University
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Su Juan
Department Of Dermatology Xiangya Hospital Central South University
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Chen Ming
School Of Pharmacy Shanghai Jiaotong University
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Zhang Wei
Department Of Anesthesiology First Affiliated Hospital Zhengzhou University
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Liu Xiao-Hua
Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, People's Republic of China
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Chen Ming
School of Pharmaceutical Sciences, Southern Medical University
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