Four New Sesquiterpenoids from the Roots of Incarvillea arguta and Their Inhibitory Activities against Lipopolysaccharide-Induced Nitric Oxide Production
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概要
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Four new sesquiterpenoids, argutosines A—D (1—4), together with two known ones (5, 6), were isolated from the roots of Incarvillea arguta. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analysis. All the sesquiterpenoids were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Argutosines A, B and C (1—3) showed potent inhibitory activities with IC50 values of 2.05, 0.55, and 9.87 μM, respectively.
著者
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Fu Jian-Jun
School of Pharmacy, Shanghai Jiao Tong University
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Qin Jiang-Jiang
School of Pharmacy, Shanghai Jiao Tong University
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Zeng Qi
School of Pharmacy, Shanghai Jiao Tong University
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Huang Ying
School of Pharmacy, Shanghai Jiao Tong University
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Jin Hui
School of Pharmacy, Shanghai Jiao Tong University
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Zhang Wei-Dong
School of Pharmacy, Shanghai Jiao Tong University
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Zhang Wei-dong
School Of Pharmacy Shanghai Jiao Tong Univ.
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Huang Ying
School Of Geophysics And Information Technol. China Univ. Of Geosciences (beijing) And Geo-detection
関連論文
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