Biflavonoids from Daphne feddei and Their Inhibitory Activities against Nitric Oxide Production
スポンサーリンク
概要
- 論文の詳細を見る
Bioassay-directed fractionation led to the isolation of two new biflavonoids and 13 known biflavonoids from a sample of the dried stem barks of Daphne feddei. The structures of compounds 1 and 2 were elucidated as 2"-methoxy-daphnodorin C (1) and 2"-methoxy-2-epi-daphnodorin C (2) on the basis of detailed spectroscopic analysis and X-ray crystallography. All 15 biflavonoids were tested for inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compounds 1, 2, 8, 10, 14 and 15 showed varying degrees of inhibitory activities against the production of NO in tested concentration of 25, 50, 75 and 100μg/ml.
- 2008-12-01
著者
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Zhang Wei-Dong
School of Pharmacy, Shanghai Jiao Tong University
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WU Zhi-Jun
Department of Research & Development, Shanghai Center of Research & Development of New Drugs
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SHEN Yun-Heng
Department of Phytochemistry, School of Pharmacy, Second Military Medical University
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Zhang Wei-dong
Department Of Phytochemistry School Of Pharmacy Second Military Medical University:school Of Pharmac
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Tang Jian
School Of Pharmacy Shanghai Jiao Tong University
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Wu Zhi-jun
Department Of Research & Development Shanghai Center Of Research & Development Of New Drugs
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Shen Yun-heng
Department Of Phytochemistry School Of Pharmacy Second Military Medical University
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Yan Shi-kai
School Of Pharmacy Shanghai Jiao Tong Univ.
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Yan Shi-kai
School Of Pharmacy Shanghai Jiao Tong University
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JIN Hui-Zi
School of Pharmacy, Shanghai Jiaotong University
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Zhang Wei-dong
School Of Pharmacy Shanghai Jiao Tong Univ.
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Jin Hui-zi
中華人民共和国
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Jin Hui-zi
School Of Pharmacy Shanghai Jiaotong University
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LIANG Shuang
School of Pharmacy, Shanghai Jiao Tong University
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TIAN Jun-Mian
Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University
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