Simultaneous Determination of Major Bioactive Components in Qingkailing Injection by High-Performance Liquid Chromatography with Evaporative Light Scattering Detection

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概要

• 論文の詳細を見る

• High-performance liquid chromatography with evaporative light scattering detection (HPLC/ELSD) was established for simultaneous determination of seven major bioactive components of Qingkailing injection including adenosine, geniposide, chlorogenic acid, baicalin, ursodeoxycholic acid, cholic acid, and hyodeoxycholic acid. The proposed method was applied to analyze ten various Qingkailing injections and produced data with acceptable linearity, repeatability, precision and accuracy having a limit of detection (LOD) of 10-50ng. In comparison with UV detection, HPLC/ELSD permits the determination of non-chromophoric compounds without prior derivatization, and shows good compatibility to the multi-components of complex analytes. The proposed method is a useful alternative for routine analysis in the quality control of traditional Chinese medicine.

• 社団法人日本薬学会の論文
• 2005-11-01

著者

• Cheng Yi-yu

  Dep. Of Chinese Medicine Sci. & Engineering Zhejiang Univ.

• YAN Shi

  Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University

• XIN Wen

  Department of Chemistry, Tsinghua University

• LUO Guo

  Department of Chemistry, Tsinghua University

• WANG Yi

  Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University

• CHENG Yi

  Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University

• Yan Shi-kai

  School Of Pharmacy Shanghai Jiao Tong Univ.

• Yan Shi-kai

  School Of Pharmacy Shanghai Jiaotong University

• Xin Wen

  Department Of Chemistry Tsinghua University:jiangxi University Of Traditional Chinese Medicine

• Yan Shi

  Pharmaceutical Informatics Institute College Of Pharmaceutical Sciences Zhejiang University

• Cheng Yi

  Pharmaceutical Informatics Institute College Of Pharmaceutical Sciences Zhejiang University

• Luo Guo-an

  中華人民共和国

• Luo Guo-an

  Department Of Chemistry Tsinghua University

• Wang Yi

  Pharmaceutical Informatics Institute College Of Pharmaceutical Sciences Zhejiang University:departme

• Yan Shi-Kai

  Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University

• Xin Wen-Feng

  Department of Chemistry, Tsinghua University

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