Effect of Interferon-y on ACNU-induced DNA Damage and Cytotoxicity in Human Glioblastoma Cells
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概要
- 論文の詳細を見る
Interferons (IFNs) are a natural body defense with powerful effects on tumor growth, including gliomas. The direct effects of IFN-y on (1-4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU)-induced deoxyribonucleic acid (DNA) damage and cytotoxicity were investigated in two human glioblastoma cell lines, A-172 and T98G, using a single cell microgel electrophoresis technique and a microculture tetrazolium assay. The results demonstrated a synergistic effect of IFN-y with ACNU on intracellular damage in both cell lines. 10μg/ml ACNU induced a cell inhibition rate of 23.9% in A-172 cells, and almost no effect on T98G cells. 1000U/ml IFN-y and 10μg/ml ACNU caused a significant increase in cell inhibition, 51.2% for A-172 and 72.3% for T98G cells. DNA damage in individual A-172 and T98G cells exposed to ACNU was enhanced significantly by IFN-y (p<0.001). The findings suggest a direct effect of IFN-y on ACNU-induced cell damage in human glioma, in addition to its effect on immunomodulation.
- 日本脳神経外科学会の論文
- 1993-05-15
著者
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HARA Akira
Department of Pathology, Gifu University School of Medicine
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ANDOH Takashi
Department of Neurosurgery,Gifu University School of Medicine
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SAKAI Noboru
Department of Neurosurgery,Gifu University School of Medicine
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ZHANG Wei
Department of Health Toxicology, School of Radiation Medicine and Public Health, Soochow University,
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Andoh Takashi
Department Of Neurosurgery Gifu University School Of Medicine
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Sakai N
Gifu Univ. School Of Medicine Gifu Jpn
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Yamakawa Hiroyasu
Department Of Neurosurgery Gifu University School Of Medicine
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YAMADA Hiromu
Department of Neurosurgery, Gifu University School of Medicine
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山川 弘保
岐阜大学医学部脳神経外科
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Hara Akira
Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University
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Zhang Wei
Department Of Cardiology Key Laboratory Of Cardiovascular Remodeling And Function Research Chinese M
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Hara Akira
Department Of Neurosurgery Gifu University School Of Medicine
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Sakai Noboru
Department Of Food Engineering Tokyo University Of Fisheries
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Yamada Hiromu
Departments Of Neurosurgery Gifu University School Of Medicine
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Yamada Hiromu
Department Of Neurosurgery Gifu University School Of Medicine
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Niikawa Shuji
Department Of Neurosurgery Gifu University School Of Medicine
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MURAKAWA Takatsugu
Department of Neurosurgery, Gifu University School of Medicine
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Zhang Wei
Department Of Neurosurgery Gifu University School Of Medicine
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Murakawa Takatsugu
Department Of Neurosurgery Gifu University School Of Medicine
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Zhang Wei
Department Of Anesthesiology First Affiliated Hospital Zhengzhou University
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