Activation of Phosphoinositide-specific Phospholipase C by Transferrin in Porcine Cerebral Arterial Smooth Muscle Cells
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概要
- 論文の詳細を見る
The effect of transferrin on phosphoinositide metabolism was investigated in smooth muscle cells isolated from the porcine basilar artery. Ferric iron-bound transferrin induced a rapid increase in the level of inositol phosphates, the metabolic products of phosphoinositides through the phospholipase C pathway. Neither transferrin free of ferric iron nor ferric iron alone caused the activation of phospholipase C. This study suggests that ferric iron-bound transferrin is capable of eliciting receptor-mediated signal transduction in porcine cerebral arterial smooth muscle cells, which could result in the contraction of smooth muscle cells. Transferrin may be involved with the cerebral arterial narrowing in pathological conditions such as subarachnoid hemorrhage.
- 日本脳神経外科学会の論文
- 1995-04-15
著者
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NAKASHIMA Toshihiko
Department of Neurosurgery, Gifu Prefectural General Medical Center
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SAKAI Noboru
Department of Neurosurgery,Gifu University School of Medicine
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NOZAWA Yoshinori
Department of Biochemistry, Gifu University School of Medicine
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Nozawa Yoshinori
Department Of Biochemistry Gifu University School Of Medicine
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Yamakawa Hiroyasu
Department Of Neurosurgery Gifu University School Of Medicine
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YANO Koh
Department of Neurosurgery, Gifu Municipal Hospital
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YAMADA Hiromu
Department of Neurosurgery, Gifu University School of Medicine
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山川 弘保
岐阜大学医学部脳神経外科
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Nakashima Toshihiko
Department Of Neurosurgery Gifu University School Of Medicine
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Yano Koh
Department Of Neurosurgery Gifu Municipal Hospital
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Sakai Noboru
Departments Of Neurosurgery Gifu University School Of Medicine
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Sakai Noboru
Department Of Food Engineering Tokyo University Of Fisheries
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Yamada Hiromu
Departments Of Neurosurgery Gifu University School Of Medicine
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Yamada Hiromu
Department Of Neurosurgery Gifu University School Of Medicine
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Kanoh Hiroyuki
Departments Of Biochemistry Gifu University School Of Medicine
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Nozawa Yoshinori
Departments Of Biochemistry Gifu University School Of Medicine
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Nakashima Toshihiko
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Kanoh Hiroyuki
Department Of Dermatology Gifu University Graduate School Of Medicine
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