Effect of APGW-Amide on [Ca^<2+>]_i in Rat Pheochromocytoma PC12 Cells
スポンサーリンク
概要
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In order to determine whether Ala-Pro-Gly-Try-NH2 (APGW-amide) could affect mammalian excitable cells, we investigated the effect of APGW-amide in PC12 cells. APGW-amide caused a rapid [Ca2+]i elevation, which was completely prevented by elimination of extracellular Ca2+ with EGTA and inhibited by two L-type Ca2+ channel blockers. [Ca2+]i elevation was also blocked by a specific PKC inhibitor and prolonged pretreatment of cells with PMA. These results indicate that APGW-amide elevates [Ca2+]i in PC12 cells, possibly by Ca2+ influx via L-type Ca2+ channel activated by PKC.
- 2000-11-01
著者
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NOZAWA Yoshinori
Department of Biochemistry, Gifu University School of Medicine
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Ito Y
Yamaguchi Univ. School Of Medicine Ube Jpn
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Han Xiao
Department Of Human Health And Nutritional Sciences University Of Guelph
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Nozawa Yoshinori
Department Of Biochemistry Gifu University School Of Medicine
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ITO Yuzuru
Department of Biochemistry, Gifu University School of Medicine
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JIANG Yifa
Virtual System Laboratory, Gifu University
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MATSUNAMI Kenichi
Department of Neurophysiology, Institute of Equilibrium Research, Gifu University School of Medicine
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Han X
Gifu Univ. Gifu Jpn
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Han Xiao
Department Of Applied Physics And Chemistry University Of Electro-communications
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Jiang Yifa
Virtual System Laboratory Gifu University
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Matsunami Kenichi
岐阜県科学技術振興センター
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Matsunami Kenichi
Department Of Neurophysiology Institute Of Equilibrium Research Gjfu University School Of Medicine
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