Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea
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概要
- 論文の詳細を見る
The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury. Albino guinea pigs were exposed to a 2 kHz pure tone of 120 or 125 dB sound pressure level for 10 min immediately after intravenous administration of DHEAS. Statistically significant improvement in the compound action potential threshold shifts and in amplitude reduction of distortion-product otoacoustic emissions was observed 1 week after the acoustic overexposure in the animals treated with DHEAS. The present results suggest that DHEAS has a protective effect against acoustic injury of the cochlea.
- 社団法人 日本薬理学会の論文
- 2005-10-20
著者
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HARA Akira
Department of Pathology, Gifu University School of Medicine
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Oikawa Keiko
Department of the First Internal Medicine, Nippon Medical School
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Oikawa Keiko
Department Of Cardiology Tokai University Hachioji Hospital
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Oikawa Keiko
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Tsuji Shigeki
Department Of Otolaryngology Institute Of Clinical Medicine University Of Tsukuba
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Tabuchi Keiji
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Tobita Tadamichi
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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UEMAETOMARI ISAO
Department of Otolaryngology, Institute of Clinical Medicine, University of Tsukuba
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Uemaetomari Isao
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Murashita Hidekazu
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Hara Akira
Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University
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Hara Akira
Department Of Otolaryngology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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HARA AKIRA
Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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