Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
スポンサーリンク
概要
- 論文の詳細を見る
Oxidative stress is demonstrated to be involved in the pathophysiological mechanism of erectile dysfunction (ED). Quercetin, a potent bioflavonoid, has been reported to have the antioxidant role. In the present study, we examined the effect of quercetin on ED and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection of STZ. The diabetic rats were then randomized to diabetic group and quercetin therapy groups which were treated with quercetin at different doses of 5, 20 and 50mg/kg per day respectively. At the end of the 8th week, erectile function was assessed by measuring the rise in intracavernous pressure (ICP) following cavernous nerve electrostimulation. Superoxide dismutase (SOD) activity, thiobarbituric acid-reacting substance (TBARS) and nitrite and nitrate (NOx) levels were measured in cavernosum tissue. Endothelial NO synthase (eNOS) expression was determined using Western blot method. ICP in diabetic rats was significantly decreased than that in controls. After treatment with quercetin at the doses of 20 and 50mg/kg, ICP was significantly increased compared to that in untreated diabetic rats. Decreased levels of SOD activity, NOx and eNOS expression, as well as elevated levels of TBARS were found in diabetic group compared with control group. Treatment with 20 and 50mg/kg quercetin improved SOD activity, NOx and TBARS levels in corpus cavernosum of diabetic rats. Decreased expression of eNOS in diabetic rats was only ameliorated by 50mg/kg quercetin treatment. Quercetin could ameliorate ED in diabetic rats by inhibiting oxidative stress.
著者
-
Zhang W
Institute For Materials Research Tohoku University
-
Zhang Wei
Institute For Materials Research Tohoku University
-
Zhang W
Data Storage Institute
-
Zhang W
Japan Sci. And Technol. Agency Sendai Jpn
-
Zhang W
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
-
Zhang Wei
Coll. Of Life Sci. Northwest Univ.
-
Wang Yong
Department Of Agricultural Biotechnology College Of Agriculture And Life Sciences Seoul National Uni
-
Bao Tingyi
Department Of Urology Tangdu Hospital The Fourth Military Medical University
-
Ma Jianjun
Department Of Urology Xijing Hospital The Fourth Military Medical University:tangdu Hospital The Fou
-
Bao Tingyi
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Zhang Wei
Department Of Anesthesiology First Affiliated Hospital Zhengzhou University
-
Qiu Jianxin
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Yang Zengyue
Department of Urology, Tangdu Hospital, Fourth Military Medical University
-
Zhao Zhiguang
Department of Urology, Tangdu Hospital, Fourth Military Medical University
-
Yang Zengyue
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Zhao Zhiguang
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Ma Jianjun
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Wang Yong
Department Of Urology Tangdu Hospital Fourth Military Medical University
-
Ma Jianjun
Department of Metallurgy, Anshan Institute of Iron and Steel Technology
関連論文
- Glass-Forming Ability and Properties of New Au-Based Glassy Alloys with Low Au Concentrations
- Oxide Glass/Amorphous Metal Alloy Laminated Membrane for Hydrogen Separation
- The efficacy and safety of sildenafil in Chinese patients with pulmonary arterial hypertension
- Microstructures of Pd_Ag_La_5 Alloy Studied by Transmission Electron Microscopy
- Formation and Mechanical Properties of New Cu-Rich Cu-Zr-Al-Ag Glassy Alloys with High Glass-Forming Ability
- Unusual Glass-Forming Ability of New Zr-Cu-Based Bulk Glassy Alloys Containing an Immiscible Element Pair
- Fabrication of New Cu_Pd_2Zr_Ag_8Al_8 Bulk Glassy Alloy with a Diameter of 30mm
- Unusual Plasticity of the Particulate-Reinforced Cu-Zr-Based Bulk Metallic Glass Composites
- Influence of Al and Ag on the Devitrification Behavior of a Cu-Zr Glassy Alloy
- Transition from Plasticity to Brittleness in Cu-Zr-Based Bulk Metallic Glasses
- Preparation of Cu_Zr_Ag_8Al_8 Bulk Metallic Glass with a Diameter of 25mm by Copper Mold Casting
- Bulk Metallic Glass Formation near a Quaternary Cu-Zr-Ti-Al Eutectic Point
- Nanocrystallization of Cu_Zr_Ti_5 Metallic Glass Induced by Electron Irradiation
- Formation and Properties of New La-Based Bulk Glassy Alloys with Diameters up to Centimeter Order
- Synthesis and Thermal Stability of New Ni-Based Bulk Glassy Alloy with Excellent Mechanical Properties
- Effects of Additional Hf on the Thermal Stability and Mechanical Properties of Cu-Zr-Ag Bulk Glassy Alloys
- Effect of Lanthanide Element on Glass-Forming Ability and Local Atomic Structure of Fe-Co-(Ln)-B Amorphous Alloys
- Influences of Temperature and Strain Rate on Mechanical Behavior of a Cu_Zr_Al_5Ag_5 Bulk Glassy Alloy
- Cu_Zr_Al_5Ag_5 Bulk Glassy Alloy with Enhanced Compressive Strength and Plasticity at Cryogenic Temperature
- Effect of Tantalum on Corrosion Resistance of Ni-Nb(-Ta)-Ti-Zr Glassy Alloys at High Temperature
- New Cu-Zr-Al-Nb Bulk Glassy Alloys with High Corrosion Resistance
- Effects of Additional Elements on the Glass Formation and Corrosion Behavior of Bulk Glassy Cu-Hf-Ti Alloys
- Corrosion Behavior of Cu-Zr-Ti-Nb Bulk Glassy Alloys
- Synthesis, Crystal Structure, and Nonlinear Optical Property of Two New Chromophores Containing Furan Ring as a Conjugation Bridge
- Arylaldehydes-pentafluorophenyl Hydrazones as Second-order Nonlinear Optical Chromophores : A Novel Approach for Remarkably Defeating the Nonlinearity-transparency Trade-off
- Excellent Mechanical Properties of Cu-Hf-Ti-Ta Bulk Glassy Alloys Containing In-Situ Dendrite Ta-based BCC Phase
- β-Catenin in early development of the lancelet embryo indicates specific determination of embryonic polarity
- Specificities of the Early Body Formation in the Lancelet Embryo
- Cloning and Embryonic Expression of Bblim3, a LIM Homeobox Gene in Amphioxus (Branchiostoma belcheri tsingtauense)
- Amorphous Nd-Fe-Si Thick Ribbons and Their Hard Magnetic Properties
- Hard Magnetic Bulk Amorphous Nd-Fe-Al Alloys of 12 mm in Diameter Made by Suction Casting
- Bulk Nd-Fe-Al Amorphous Alloys with Hard Magnetic Properties
- Neutrophils, Not Complement, Mediate the Mortality of Experimental Hemorrhagic Pancreatitis
- Low-Temperature Synthesis of C-Axis-Oriented Polycrystalline Aluminum Nitride Films by Electron Cyclotron Resonance Plasma Chemical Vapor Deposition Using AlBr_3-N_2-H_2-Ar Gas System
- Visualization of Head-Disk Contact Using a Low Curie Temperature Media
- Automated Experimental Assembly for Studying the Reaction-Diffusion Behavior of Belousov-Zhabotinsky Reactions under Microgravity
- Consolidation of Fe-Co-Nd-Dy-B Glassy Powders by Spark-Plasma Sintering and Magnetic Properties of the Consolidated Alloys
- Synthesis and Mechanical Properties of Cu-Based Cu-Zr-Ti Bulk Glassy Alloys Containing ZrC Particles
- Glass-Forming Ability, Crystallized Structure and Magnetic Properties of Fe_Co_Nd_3Dy_B_ Glassy Alloy with Large Supercooled Liquid Region
- Hard Magnetic Properties and Nanocrystallized Structure of Fe_Co_Pr_B_ Glassy Alloy
- Glass-forming ability and mechanical properties of the ternary Cu-Zr-Al and quaternary Cu-Zr-Al-Ag bulk metallic glasses (Special issue on bulk metallic glasses: selected papers from the fifth international conference on bulk metallic glasses (BMGV))
- Electro-acupuncture induced NGF, BDNF and NT-3 expression in spared L6 dorsal root ganglion in cats subjected to removal of adjacent ganglia
- A New Soft Magnetic Bulk Metallic Glass with Dual Glass Phases
- Microstructure Feature of Bulk Glassy Cu_Zr_Ti_ Alloy in As-cast and Annealed States
- Thermal Stability and Mechanical Strength of Bulk Glassy Ni-Nb-Ti-Zr Alloys
- Estimation of Correlation of Acoustic Reciprocal Transmissions Using Central Equatorial Pacific Tomography Data
- Estimation of the Stability of Acoustic Reciprocal Transmission in Long-Range Propagation at the Central Equatorial Pacific
- Comparative Study of Head-Disk Spacing Measurement Techniques between Optical Method and Various In-Situ Methods(Special Issue on Recent Progress in Information Storage Technology)
- Visualization of tribologically induced energy disturbance to the stability of high density magnetic recording (マルチメディアストレージ 第6回アジア情報記録技術シンポジウム〔英文〕)
- Comparative study of head-disk spacing measurement techniques between optical method and various in-situ methods (マルチメディアストレージ 第6回アジア情報記録技術シンポジウム〔英文〕)
- Visualization of Tribologically Induced Energy Disturbance to the Stability of HIgh Density Magnetic Recording
- Comparative Study of Head-Disk Spacing Measurement Techniques between Optical Method and Various In-Situ Methods
- Tribo-magnetics:concept and investigations (マルチメディアストレージ--第5回アジア情報記録技術シンポジウム〔英文〕)
- Tribo-magnetics : Concept and Investigations
- Micro Recording Performance Fluctuation and Magnetic Roughness Analysis : Methodology and Application(Special Issue on Selected Papers from the 4th Asian Symposium for Information Storage Technology)
- Magnetic Roughness Analysis:Methodology and Application (第4回アジア情報記録技術シンポジウム〔英文〕)
- Magnetic Roughness Analysis: Methodology and Application
- Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese Population
- Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese
- Synthesis of Hard Magnet Materials by Uniaxial Hot-Pressing of fe-Co-Nd-Dy-B Glassy Powders (特集 永久磁石材料とその応用)
- In situ Formed (Cu_
- Cu-Based Bulk Glassy Alloys with Good Mechanical Properties in Cu-Zr-Hf-Ti System
- High-Strength Cu-Based Bulk Glassy Alloys in Cu-Zr-Ti-Be System
- Thermal and Mechanical Properties of Cu-Based Cu-Zr-Ti Bulk Glassy Alloys
- Effect of Smoking on Chromosomes Compared with That of Radiation in the Residents of a High-Background Radiation Area in China
- Imperceptible Effect of Radiation Based on Stable Type Chromosome Aberrations Accumulated in the Lymphocytes of Residents in the High Background Radiation Area in China
- O-06. Chromosome aberrations in the lymphocytes of residents in the high background radiation area in Guangdong province in China(Abstracts of the oral and poster presentations, Abstracts of the 54th Annual Meeting of the Society of Chromosome Research)
- Chromosome Translocation in Residents of the High Background Radiation Areas in Southern China
- Generation of Reactive Oxygen Species from Hinokitiol under Near-UV Irradiation(Analytical Chemistry)
- Synthesis of a Cyclodextrin Heterodimer Having α-and β-Cyclodextrin Units and Its Cooperative and Site-Specific Binding
- Syntheses and Molecular Recognition Abilities of 6-O-, 2-O-, and 3-O-Dansyl-γ-Cyclodextrins
- Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization
- Rapid determination of acetone in human plasma by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization
- Synthesis and Thermal Stability of New Ni-Based Bulk Glassy Alloy with Excellent Mechanical Properties
- Thermal Stability and Soft Magnetic Properties of (Fe, Co)-(Nd, Dy)-B Glassy Alloys with High Boron Concentrations
- Thermal Stability and Magnetic Properties of Fe-Co-Pr-B Amorphous Alloys with a Supercooled Liquid Region
- Effect of Dy Addition on the Thermal Stability and Magnetic Properties of the Fe-Co-Nd-B Amorphous Alloys with Supercooled Liquid Region
- Expression of NDRG2 in Clear Cell Renal Cell Carcinoma(Molecular and Cell Biology)
- Formation, Crystallized Structure and Magnetic Properties of Fe-Pt-B Amorphous Alloys
- Microstructure and mechanical properties of porous Zr55Cu30Al10Ni5 bulk metallic glass fabricated by spark plasma sintering process (Special issue on bulk metallic glasses: selected papers from the fifth international conference on bulk metallic glasses (
- Study on Magnetic Tunnel Junction(Special Issue on Selected Papers from the 5th Asian Symposium on Information Storage Technology)
- Evidence for Muscarinic 3 Receptor Mediated Ion Transport in HT29 Cells Studied by X-ray Microanalysis
- Experimental System Assembled for Studying the Chemical Oscillation Behavior of Belousov-Zhabotinskii Reactions in the Microgravity
- Oxygen-Ordering Effects in High-T_c Superconductors
- Simple Purification of a Foreign Protein Using Polyhedrin Fusion in a Baculovirus Expression System
- A Novel Black-Aluminum Deposition System for CRT (情報ディスプレイ--The 6th Asian Symposium on Information Display & Exhibition)
- A Novel Black-Aluminum Deposition System For CRT
- Laparoscopic assisted endorectal pull-through with posterior sagittal approach to the repair of postoperative rectourethral and rectovaginal fistula
- Microstructure and Mechanical Properties of (Zr_Cu_Al_)_Ta_x Bulk Metallic Glass Composites
- Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Interlace Strategy of Video and Audio PTSs in MPEG-2 TS(Multimedia Svstems for Communications)
- Reactive oxygen species and hematopoietic stem cell senescence
- Mitigation of Ionizing Radiation-induced Bone Marrow Suppression by p38 Inhibition and G-CSF Administration
- Fractal Scale Indication of Oil-Water Two Phase Flow Characteristics
- Preparation of Al-O-N Films by Electron Cyclotron Resonance Plasma-Assisted Chemical Vapor Deposition
- Rate Distortion Optimized Coding Mode Selection for H.264/AVC in Wireless Environments(Multimedia Systems)
- A novel high-voltage trench gate insulated gate bipolar transistor with diffusion remnant layer
- Preparation of Al–O–N Films by Electron Cyclotron Resonance Plasma-Assisted Chemical Vapor Deposition
- Silicon Nitride Nanorings: Synthesis and Optical Properties
- Al_TiZrPdCuNi High-Entropy (H-E) Alloy Developed through Ti_Zr_Pd_Cu_Ni_ H-E Glassy Alloy Comprising Inter-Transition Metals