Expression of NDRG2 in Clear Cell Renal Cell Carcinoma(Molecular and Cell Biology)
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概要
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Clear cell renal cell carcinoma (CCRCC) is the most common pathological type of renal cell carcinoma and the main cause of renal carcinoma mortality. NDRG2, a new member of the N-Myc downstream-regulated gene (NDRG) family, is a focus for study at present. Up to now, its expression and function in carcinoma remain unclear. The aim of this study was to investigate its expression in CCRCC tissues and several renal carcinoma cell lines. The expression of NDRG2 was evaluated in renal cell carcinoma cell lines, tumor and adjacent non-tumor tissues from same clear cell renal cell carcinoma patients, by using immunohistochemistry, immunofluorescence, RT-PCR and Western blot. By immunohistochemistry and immunofluorescence we found that NDRG2 was pre-dominantly located in the cytoplasm and membrane of renal carcinoma cancer cells, and the positive rate of NDRG2 in renal carcinoma specimens was 30.3% (40/132), which is significantly lower than 91.67% (121/132) in normal renal tissues (p<0.01). The average staining score in normal renal tissues was significantly higher than renal carcinoma (6.12±1.84 versus 2.65±1.23, p<0.01). Moreover, NDRG2 mRNA and protein were down-regulated in 6 fresh CCRCC tissues compared with their adjacent noncancerous tissues and normal tissues. Its expression was also lower in the human CCRCC-derived cell lines A-498 and 786-O than in the human proximal tubular cell lines HK-2 and HKC. These results indicated that NDRG2 might play an important role in the carcinogenesis and development of CCRCC and may function as a tumor suppressor in CCRCC.
- 2008-07-01
著者
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Zhang W
Institute For Materials Research Tohoku University
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Zhang Wei
Institute For Materials Research Tohoku University
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Zhang W
Data Storage Institute
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Yao Libo
State Key Laboratory Of Cancer Biology Department Of Biochemistry And Molecular Biology The Fourth M
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Zhang W
Japan Sci. And Technol. Agency Sendai Jpn
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Zhang W
National Institute For Radiological Protection Chinese Center For Disease Control And Prevention
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Zhang Wei
Department Of Cardiology Key Laboratory Of Cardiovascular Remodeling And Function Research Chinese M
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Jiang Xue
Department Of Physics Faculty Of Science Tohoku University:changchun Institute Of Physics Chinese Ac
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ZHAO Huadong
Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University
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YAO Libo
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical
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Zhao Huadong
State Key Laboratory Of Cancer Biology Department Of Gastrointestinal Surgery Xijing Hospital The Fo
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Jin Haifeng
State Key Laboratory Of Cancer Biology Department Of Gastrointestinal Surgery Xijing Hospital The Fo
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Wang He
Tangdu Hospital The Fourth Military Medical University
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Zhang Wei
Coll. Of Life Sci. Northwest Univ.
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MA Jianjun
Department of Urology, Xijing Hospital, the Fourth Military Medical University
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YUAN Jianlin
Tangdu Hospital, the Fourth Military Medical University
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BAO Tingyi
Department of Urology, Tangdu Hospital, the Fourth Military Medical University
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Bao Tingyi
Department Of Urology Tangdu Hospital The Fourth Military Medical University
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Ma Jianjun
Department Of Urology Xijing Hospital The Fourth Military Medical University:tangdu Hospital The Fou
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Yuan Jianlin
Tangdu Hospital The Fourth Military Medical University
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Bao Tingyi
Department Of Urology Tangdu Hospital Fourth Military Medical University
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Zhang Wei
Department Of Anesthesiology First Affiliated Hospital Zhengzhou University
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Ma Jianjun
Department Of Urology Tangdu Hospital Fourth Military Medical University
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Jiang Xue
Department Of Operation Room Tangdu Hospital The Fourth Military Medical University
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Jin Haifeng
State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University
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Ma Jianjun
Department of Metallurgy, Anshan Institute of Iron and Steel Technology
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