11 レイナマイシンの全合成(口頭発表の部)
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概要
- 論文の詳細を見る
The first total synthesis of novel antitumor antibiotic (+)-leinamycin (1) is reported. The unique structural features of leinamycin include the 1-oxo-1, 2-dithiolan-3-one moiety fused in a spiro fashion to an 18-membered lactam with an extensively conjugated thiazole ring. No other natural products with such an unusual dithiolanone moiety have been reported to date. The 18-membered lactam 19 was assembled efficiently from Seebach's dioxolanone 2 via sequential chemo- and stereoselective reactions including iterative application of our versatile thiol ester reductions. The delicate dithiolanone moiety of 1 was constructed stereoselectively by critical intramolecular delivery of a sulfur atom and the ensuing Beckmann fragmentation.
- 天然有機化合物討論会の論文
- 1993-09-10
著者
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神田 裕
協和発酵・東京研
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斎藤 裕
協和発酵東京研
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福山 透
東大院薬
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神田 裕
協和発酵東京研
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斉藤 博満
協和発酵東京研
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福山 透
ライス大化
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斉藤 博満
協和発酵・東京研
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Kanda Yutaka
Kyowa Hakko Kogyo Co. Ltd. Tokyo Research Laboratories
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Saito H
Department Of Pharmacology College Of Pharmacy Nihon University
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