81(P2-11) カルモジュリン依存性ホスホジエステラーゼ阻害物質KS-506類の構造決定(ポスター発表の部)

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KS-506f(1), p(2), a(3), x(4), g(5) have been isolated from culture broth of Mortuerella vinacea as a potent inhibitors of calmodulin-dependent phosphodiesterase. Structures of these novel sulfer-containing depsides are described. KS-506f and p were identified to be 1 and 2. 3, 4, 5 were found to be the dimeric compounds composed by component I and II through S-S linkage, which are converted each other by disproportionation reaction. The structure of 3 was determined to be dimeric thiocarboxylic acid of component I by COLOC experiment, degradation to afford 1 by methanolysis, and chemical conversion to methylthioester (8) and cyclic diester (9). Confirmation of the structures of 4 and 5 were accomplished using COLOC data of 3-oxobutylthio ether of component II (10) to be dithioester and disulfide, respectively. Methanolysis of KS-506s gave KS-506h(6) and m(7). 6 was methyl ester of component I. The COLOC spectrum of 7 suggested that 7 is the 3-oxobutylthio ester of component I. 7 was produced on treatment 4 with Ph_3P and methyl vinyl ketone, which also assisted its structure.
天然有機化合物討論会の論文
1989-09-17