65(P39) 新規細胞周期阻害剤UCK14Aの構造決定(ポスター発表の部)

概要

論文の詳細を見る
In the course of screening for cell cycle inhibitors, UCK14A was isolated from Streptomyces sp. We report here on the structural elucidation of UCK14A, a novel peptide, using MS and NMR investigations. Spectral analysis revealed that this compound possesed unique structures, a novel amino acid, 3-(2-aminocyclopropyl)-alanine (AcpAla), and a β-lactone. Furthermore, we determined the absolute structure of UCK14A. The configuration of Ala was elucidated by the DL-amino acid analysis using chiral GC-MS. The stereochemistries of acyl sidechain and AcpAla were investigated by conformation and configuration analysis (Matsumori's method), modified Mosher's method, and conformation searches. Finally, those stereostructures were confirmed by synthetic approaches.
天然有機化合物討論会の論文
1999-09-01