76 新抗腫瘍性抗生物質テトロカルシンの構造

概要

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Tetrocarcins are new antitumor antibiotics produced by Micromonospora chalcea KY11091, and show marked activity against experimental tumors such as mouse sarcoma 180 and mouse leukemia P388. Acid hydrolysis of tetrocarcin A and B gave a novel aglycone (tetronolide, C_<32>H_<40>O_8), a new nitrosugar (tetronitrose, C_9H_<16>N_2O_6), L-amicetose and L-digitoxose. The structures of tetronolide and tetronitrose were confirmed by spectroscopic and X-ray crystallographic analyses except the absolute configuration. The structures of tetrocarcin A (C_<67>H_<96>N_2O_<24>) and B (C_<61>H_<86>N_2O_<22>) have been determined as depicted in (22) and (23), respectively, on the basis of the conversion of tetrocarcin A into B by incubation with intact cells and methanolysis of permethylated tetrocarcin A and permethylated deacetyldihydrotetrocarcin A giving methyl 4-O-methyl-L-amicetoside and methyl 3-O-methyl and 4-O-methyl-L-digitoxosides.
天然有機化合物討論会の論文
1980-09-10