79 新マイトマイシン,その構造決定と相互変換及び活性について

概要

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Mitomycins (MM)(Fig. 1) were discovered first by Hata et al.in 1956 and by Wakaki et al.in 1958. MM-C has broad and highly potent antibacterial and anticancer activity but it also has strong toxicity as other anticancer agents have. Many chemical modification of MM have been tried to obtain their analogs with stronger activity or with less toxicity than the parent MM. As one of approaches to the goal, we have surveyed the broth of MM-C fermentation in detail and found that there are co-produced several minor components belonging to the family of MM. By a series of isolation procedure, nine natural MM were obtained. They were named as MM-D, E, F, G, I, J, K, L, and M in the order of isolation and their structures have been elucidated as shown in Fig. 2 and 4 by spectroscopic method and chemical transformation. MM-F is N-methyl MM-A. Six of them (MM-D, E, F, J, L, and M) were known compounds which had been already derived from the known MM although three of them (MM-E, J, and L) were believed to have the wrong structures depicted in Fig. 5. MM-G and K are new type of the class of mitomycins with exocyclic methylene. Their antibacterial and anticancer activity will be also discussed.
天然有機化合物討論会の論文
1980-09-10