Lack of Association between Endoplasmic Reticulum Stress Response Genes and Suicidal Victims
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概要
- 論文の詳細を見る
As lithium has been shown to have a protective effect against suicidal behavior,genes on which mood stabilizers act may be involved in biological susceptibility tosuicide. A recent study showed that endoplasmic reticulum (ER) stress response wasimpaired in the bipolar disorders and the impairment was ameliorated by a moodstabilizer, valproate. We hypothesized that an alteration of ER stress response isinvolved in the biological susceptibility to suicide through genetic polymorphisms, andexamined the association of polymorphisms of X-box binding protein 1 (XBP1) andheat shock 70-kDa protein 5 (HSPA5) genes with suicide. We found no significantdifference in the distribution of these polymorphisms between the suicide victims andthe controls. These results suggest that the polymorphisms examined in this study arenot involved in the susceptibility to suicide of the Japanese.
- 神戸大学の論文
著者
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HAYASHI Yoshitake
Division of Molecular Medicine & Medical Genetics, International Center for Medical Research and Tre
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Maeda Kiyoshi
Kobe Univ. Graduate School Of Health Sci. Kobe Jpn
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SAKURAI KAORU
Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and T
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Maeda Kiyoshi
Department Of Surgical Oncology Osaka City University Graduate School Of Medicine
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Sakurai Kaoru
Division Of Molecular Medicine & Medical Genetics International Center For Medical Research And
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Sakurai Kaoru
Division Of Gastroenterology And Hepatology Musashino Red Cross Hospital
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NUSHIDA HIDEYUKI
Department of Legal Medicine, Kobe University Graduate School of Medicine
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UENO YASUHIRO
Department of Legal Medicine, Kobe University Graduate School of Medicine
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Nishiguchi Naoki
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Shirakawa Osamu
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Maeda Kiyoshi
Department Of Psychiatry And Neurology Kobe Graduate School Of Medicine
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Ueno Yasuhiro
Department Of Legal Medicine Kobe University Graduate School Of Medicine
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Ueno Yasuhiro
Nippon Kokan Koji Co.
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Hayashi Yoshitake
Division Of Molecular Medicine & Medical Genetics International Center For Medical Research And
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Shirakawa Osamu
Department Of Neuropsychiatry Kinki University School Of Medicine
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Nishiguthi Naoki
Kobe University Graduate School of Medicine
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Nushida Hideyuki
Department Of Legal Medicine Kobe University Graduate School Of Medicine
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Nushida Hideyuki
Division Of Legal Medicine Department Of Social Medicine Kobe University Graduate School Of Medicine
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MAEDA Kiyoshi
Department of Pharmacology, Nagoya University School of Medicine
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Maeda Kiyoshi
Department of Medical Rehabilitation, Kobe Gakuin University
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