No Evidence of an Association Between Tyrosine Hydroxylase Gene Polymorphisms and Suicide Victims
スポンサーリンク
概要
- 論文の詳細を見る
Functional alternations of noradrenergic and dopaminergic neurotransmission havebeen implicated in suicidal behavior. A tetranucleotide repeat polymorphism in thefirst intron of the tyrosine hydroxylase (TH) gene, encoding a rate-limiting enzyme forthe synthesis of catecholamines, is reported to have the potential to control expressionof the gene and to be associated with suicidal behavior in patients with adjustmentdisorders. To test the hypothesis that TH gene polymorphisms are involved in suicidethrough an alteration of TH function, this tetranucleotide repeat polymorphism and theother two SNPs that cause a change in amino acid sequence were examined in suicidevictims who completed suicide and control subjects. No significant differences ingenotype distribution or allele frequencies were found between the two groups in thethree polymorphisms. These findings suggest that these functional polymorphisms arenot involved in a biological susceptibility to suicide.
- 神戸大学の論文
著者
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Maeda Kiyoshi
Kobe Univ. Graduate School Of Health Sci. Kobe Jpn
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Maeda Kiyoshi
Department Of Surgical Oncology Osaka City University Graduate School Of Medicine
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NUSHIDA HIDEYUKI
Department of Legal Medicine, Kobe University Graduate School of Medicine
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UENO YASUHIRO
Department of Legal Medicine, Kobe University Graduate School of Medicine
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Nishiguchi Naoki
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Shirakawa Osamu
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Hattori Haruki
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Maeda Kiyoshi
Department Of Psychiatry And Neurology Kobe Graduate School Of Medicine
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Ueno Yasuhiro
Department Of Legal Medicine Kobe University Graduate School Of Medicine
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Ueno Yasuhiro
Nippon Kokan Koji Co.
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Hattori Haruki
Department Of Psychiatry And Neurology Kobe University Graduate School Of Medicine
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Shirakawa Osamu
Department Of Neuropsychiatry Kinki University School Of Medicine
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Nishiguthi Naoki
Kobe University Graduate School of Medicine
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Nushida Hideyuki
Department Of Legal Medicine Kobe University Graduate School Of Medicine
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Nushida Hideyuki
Division Of Legal Medicine Department Of Social Medicine Kobe University Graduate School Of Medicine
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MAEDA Kiyoshi
Department of Pharmacology, Nagoya University School of Medicine
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Maeda Kiyoshi
Department of Medical Rehabilitation, Kobe Gakuin University
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