Lack of Association between the Dopamine Transporter Gene 3'VNTR Polymorphism and Attention Deficit Hyperactivity Disorder in Chinese Han Children : Case-control and Family-based Studies
スポンサーリンク
概要
- 論文の詳細を見る
Attention deficit hyperactivity disorder (ADHD) is the most common childhoodonset neurodevelopment disorder. The etiology is unclear, but is suspected to involvethe dopamine system. In this study we used the haplotype-based haplotype relative risk(HHRR) analysis and the transmission disequilibrium test (TDT) to investigate thepotential contribution of dopamine transporter (DAT1) gene variants to ADHD. DAT1gene polymorphisms were assessed in 54 ADHD Chinese Han children and all 108 oftheir parents and 66 normal child controls. No differences were found in eithergenotype or allele distributions. The HHRR analysis of the DAT1 polymorphismssuggests that the transmission of this polymorphism is not significantly associated withADHD. And the TDT result showed that ADHD was not in linkage with the DAT1 gene.These findings do not support the hypothesis that DAT1 gene variants contribute to thepathogenesis of ADHD in Chinese Han population.
- 神戸大学の論文
著者
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Maeda Kiyoshi
Department Of Surgical Oncology Osaka City University Graduate School Of Medicine
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TANAKA Kiwamu
Department of Agricultural Sciences and Natural Resources, Faculty of Agriculture, Kagoshima Univers
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Shirakawa Osamu
Department of Psychiatry and Neurology, Kobe University Graduate School of Medicine
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Maeda Kiyoshi
Department Of Psychiatry And Neurology Kobe Graduate School Of Medicine
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Zhaohui Wang
Department Of Psychiatry And Psychology Second Affiliated Hospital Xi'an Jiaotong University
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Tanaka Kiwamu
Department Of Agricultural Sciences And Natural Resources Faculty Of Agriculture Kagoshima Universit
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Tanaka Kiwamu
Department Of Psychiatry And Neurology Kobe University Graduate School Of Medicine
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Shirakawa Osamu
Department Of Neuropsychiatry Kinki University School Of Medicine
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Shirakawa Osamu
Department Of Psychiatry And Neurology Kobe University Graduate School Of Medicine
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YAPING WANG
Department of Psychiatry and Psychology, Second Affiliated Hospital, Xi'an Jiaotong University
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KAINAN YAO
Department of Psychiatry and Psychology, Second Affiliated Hospital, Xi'an Jiaotong University
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YUFENG YANG
Department of Psychiatry and Psychology, Second Affiliated Hospital, Xi'an Jiaotong University
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Kainan Yao
Department Of Psychiatry And Psychology Second Affiliated Hospital Xi'an Jiaotong University
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Yaping Wang
Department Of Psychiatry And Psychology Second Affiliated Hospital Xi'an Jiaotong University
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Yufeng Yang
Department Of Psychiatry And Psychology Second Affiliated Hospital Xi'an Jiaotong University
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MAEDA Kiyoshi
Department of Pharmacology, Nagoya University School of Medicine
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Maeda Kiyoshi
Department of Medical Rehabilitation, Kobe Gakuin University
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