Antimuscarinic effects of antihistamines : Quantitative evaluation by receptor-binding assay.
スポンサーリンク
概要
- 論文の詳細を見る
Quantitative evaluation of antimuscarinic effects of antihistamines (H<SUB>1</SUB>and H<SUB>2</SUB>-receptor antagonists) was carried out using a receptor-binding assay. The inhibition constants (K<SUB>1</SUB> values) of twenty seven H<SUB>1</SUB>-receptor antagonists, one related antidepressant and three H<SUB>2</SUB>-receptor antagonists at H<SUB>1</SUB>-receptors and muscarinic receptors in the bovine cerebral cortex were determined. All the H<SUB>2</SUB>receptor antagonists examined showed very low affinity for the muscarinic receptors. On the other hand, some H<SUB>1</SUB>-receptor antagonists (mequitazine, cyproheptazine, clemastine, diphenylpyraline, promethazine, homochlorcyclizine and alimemazine) had high affinity for the muscarinic receptors (K<SUB>1</SUB>=5.0-38 nM). Another group of H<SUB>1</SUB> -receptor antagonists (mepyramine, terfenadine, metapyrilen, azelastine, hydroxyzine and meclizine) had low affinity for the muscarinic receptors (K<SUB>1</SUB>=3, 600-30, 000 nM). Thus, a broad range of antimuscarinic potencies among the antihistamines was demonstrated. These results should provide helpful information with regard to the clinical and experimental use of antihistamines.
- 公益社団法人 日本薬理学会の論文
著者
-
Shirakawa Osamu
Department Of Neuropsychiatry Kinki University School Of Medicine
-
Tanaka Chikako
Department Of Anesthesiology Keio University School Of Medicine
-
Kuno Takayoshi
Department Of Genome Sciences Kobe University Graduate School Of Medicine
-
Kubo Nobuo
Department Of Otolaryngology Kansai Medical University
-
SHIRAKAWA Osamu
Department of Pharmacology, Kobe University School of Medicine
関連論文
- Voxel Dimensions Required for Micromorphologic Evaluation of Ground-glass Opacity on Lung High-resolution CT
- Stereoscopic Scintigraphic Imaging of Breast Cancer Sentinel Lymph Nodes
- IMMUNOCYTOCHEMICAL LOCALIZATION OF PROTEIN KINASE C SUBSPECIES IN RAT STRIONIGRAL SYSTEM
- EXPRESSION AND LOCALIZATION OF PROTEIN KINASE C IN RAT BRAIN
- IMMUNOCYTOCHEMICAL LOCALIZATION OF PROTEIN KINASE C SUBSPECIES IN RAT HIPPOCAMPUS
- Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia
- Physiological tolerance of Camellia rusticana leaves to heavy snowfall environments : The effects of prolonged snow cover on evergreen leaves
- Association Study of RGS2 Gene Polymorphisms with Panic Disorder in Japanese
- Lack of Association between Endoplasmic Reticulum Stress Response Genes and Suicidal Victims
- No Evidence of an Association Between Tyrosine Hydroxylase Gene Polymorphisms and Suicide Victims
- Association of 14-3-3 ε gene haplotype with completed suicide in Japanese
- Oblique view of preoperative lymphoscintigraphy improves detection of sentinel lymph nodes in esophageal cancer
- Structural Study of Silk-like Peptides Modified by the Addition of the Cell Adhesive Sequence, RGD, Using ^C CP/MAS NMR
- Pulsed NMR Study of the Curing Process of Epoxy Resin
- Immunohistochemical approach for differential expression of protein kinase C subspecies
- Immunohistochemical Localization of Cyclic Nucleotides in the Rat Articular Cartilage and Synovial Membrane
- Lack of Association between the Dopamine Transporter Gene 3'VNTR Polymorphism and Attention Deficit Hyperactivity Disorder in Chinese Han Children : Case-control and Family-based Studies
- INHIBITORY EFFECT OF (+)THREO-3, 4-DIHYDROXY-PHENYLSERINE (DOPS) ON DECARBOXYLATION OF (-)THREO-DOPS
- NEONATAL AND SENESCENT CHANGES IN L-AROMATIC AMINO ACID DECARBOXYLASE AND MONOAMINE OXIDASE ACTIVITIES IN KIDNEY, LIVER, BRAIN AND HEART OF THE RAT
- 6. Effect of Amantadine on Serotonin Metabolism in Rat Brain
- The neurobiology of suicide
- Immunohistochemical Localization of GABA and Aspartate in the Rat Pancreas
- Characterization and Purification of Aspartate Antiserum and its application to Immunohistochemistry
- Immunohistochemistry of GABA and aspartate in the vestibular nuclei of the guinea pig
- Studies on Fungal Pumilio Gene Family through Mining Multiple Genome-Scale Data Sets
- Fluorescence Histochemical Demonstration of Adrenergic Nerve Fibers in the Hip Joint Capsule
- The Locus Coeruleus of the Rhesus Monkey;Noradrenergic Cell Distribution and its Ascending Projection
- Inhibitory effects of monoamine oxidase inhibitors on the growth of pea and rice seedlings
- Electron-Phonon Interaction Mechanism of Temperature Induced Ferromagnetism : II. LOW TEMPERATURE PROPERTIES OF SOLIDS : Magnetism : Rare Earth etc.
- Photoaffinity labeling of the D_1 dopamine receptor : I. Biochemical basis of microautoradiography
- Photoaffinity labeling of the D_1 dopamine receptor : II. Application to microautoradiography
- HISTOCHEMICAL STUDY OF THE CENTRAL MONOAMINE NEURON SYSTEMS IN THE TORTICOLLIS OF CAT (SYMPOSIUM ON HISTOCHEMISTRY AND CYTOCHEMISTRY OF NEUROTRANSMITTERS AND ITS CLINICAL APPLICATION)
- Plasma Nucleosome Levels in Node-Negative Breast Cancer Patients
- P-glycoprotein Limits the Brain Penetration of Olopatadine Hydrochloride, H1-Receptor Antagonist
- LEVELS OF TYROSINE AND TRYPTOPHAN IN THE PLASMA AND BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
- Immunocytochemical Localization of cyclic AMP and cyclic GMP in Synchronously Dividing Tetrahymena
- ENZYMATIC DECARBOXYLATION OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE IN RAT HEART
- DOPAMINE ACCUMULATION IN THE MOUSE BRAIN UNDER HYPOXIA
- THIAMINE ACCUMULATION INDUCED BY L-5-HYDROXY-TRYPTOPHAN IN RAT BRAIN
- Microspectrofluorometric Identification and Quantitative Histochemistry of Biogenic Amines (Histochemistry of Bioactive Amines)
- SKELETAL CHANGES INDUCED BY DOPA DECARBOXYLASE INHIBITOR IN RATS
- Evidence for the presence of D2 and 5-HT2 receptors in the human prefrontal cortex.
- Ascending norepinephrine pathways impaired in experimental hydrocephalus.
- Cyclic adenosine 3',5'-monophosphate levels in response to norepinephrine in rectum of postnatal rats.
- GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
- Novel type of monoclonal antibodies against cyclic GMP and application to immunocytochemistry of the rat brain.
- Role of protein kinase C in the vesicular release of acetylcholine and norepinephrine from enteric neurons of the guinea pig small intestine.
- Antimuscarinic effects of antihistamines : Quantitative evaluation by receptor-binding assay.
- (3H)GBR-12935 binding sites in human striatal membranes: Binding characteristics and changes in Parkinsonians and schizophrenics.