Role of protein kinase C in the vesicular release of acetylcholine and norepinephrine from enteric neurons of the guinea pig small intestine.
スポンサーリンク
概要
- 論文の詳細を見る
The involvement of protein kinase C in the release of[<SUP>3</SUP>H]acetylcholine (ACh) and[<SUP>3</SUP>H]norepinephrine (NE) was studied in strips of guinea pig small intestine. 12-<I>O</I>-tetradecanoyl phorbol 13-acetate (TPA), but not 4α-phorbol-12, 13-didecanoate (4α-PDD) potentiated the A23187-evoked release of [<SUP>3</SUP>H]ACh and [<SUP>3</SUP>H]NE from the strips of small intestine preloaded with [<SUP>3</SUP>H]choline and [<SUP>3</SUP>H]NE, and the potentiating effect of TPA was inhibited by polymyxin B. High K<SUP>+</SUP>-evoked releases of [<SUP>3</SUP>H]ACh and [<SUP>3</SUP>H]NE in the presence of tetrodotoxin were also potentiated by TPA. These TPA-induced potentiations of the evoked release were greater at a low concentration of external Ca<SUP>2+</SUP> (0.5 mM) than at a high concentration (2 mM). Ouabain induced the release of these neurotransmitters both in the absence and presence of the low concentration of external Ca<SUP>2+</SUP>. The ouabain-evoked release was not altered by TPA. These results indicate that the activation of protein kinase C potentiates the vesicular release of ACh and NE at low Ca<SUP>2+</SUP> concentration from the nerve terminals of enteric neurons in the guinea pig small intestine.
- 公益社団法人 日本薬理学会の論文
著者
-
Tanaka Chikako
Department Of Anesthesiology Keio University School Of Medicine
-
TANIYAMA Kohtaro
Department of Pharmacology, Kobe University School of Medicine
-
Taniyama Kohtaro
Department of Pharmacology 2, Nagasaki University School of Medicine
-
HASHIMOTO Sinya
Department of Pharmacology, Kobe University School of Medicine
-
SHUNTOH Hisato
Department of Pharmacology, Kobe University School of Medicine
関連論文
- Voxel Dimensions Required for Micromorphologic Evaluation of Ground-glass Opacity on Lung High-resolution CT
- Stereoscopic Scintigraphic Imaging of Breast Cancer Sentinel Lymph Nodes
- Acceleration by KW-5092 of Intestinal Motility Associated With Acetylcholine Release In Vivo
- μ-Opioid Receptor Forms a Functional Heterodimer With Cannabinoid CB_1 Receptor : Electrophysiological and FRET Assay Analysis
- Neuroprotective Effect of TTC-909, an Isocarbacyclin Methyl Ester Incorporated in Lipid Microspheres, on Hippocampal Delayed Neuronal Death of Stroke-Prone Spontaneously Hypertensive Rats
- Histologicak Evience for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats
- Inhibition by γ-Aminobutyric Acid System Activation of Epileptic Seizures in Spontaneously Epileptic Rats
- GTPγS-Induced Ca^ Activated C1^- Currents: Its Stable Induction by Gqα Overexpression in Xenopus Oocytes
- IMMUNOCYTOCHEMICAL LOCALIZATION OF PROTEIN KINASE C SUBSPECIES IN RAT STRIONIGRAL SYSTEM
- EXPRESSION AND LOCALIZATION OF PROTEIN KINASE C IN RAT BRAIN
- IMMUNOCYTOCHEMICAL LOCALIZATION OF PROTEIN KINASE C SUBSPECIES IN RAT HIPPOCAMPUS
- Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia
- Physiological tolerance of Camellia rusticana leaves to heavy snowfall environments : The effects of prolonged snow cover on evergreen leaves
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- In Vivo Assessment of Acceleration of Motor Activity Associated With Acetylcholine Release via 5-Hydroxytryptamine_4 Receptor in Dog Intestine
- INVOLVEMENT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) RECEPTORS IN INTESTINAL MOTILITY AND ION TRANSPORT
- Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine-4 receptor, in gastrointestinal motility
- In Vivo Microdialysis Assessment of Nerve-Stimulated Contractions Associated With Increased Acetylcholine Release in the Dog Intestine
- Oblique view of preoperative lymphoscintigraphy improves detection of sentinel lymph nodes in esophageal cancer
- Propofol Inhibits Muscarinic Acetylcholine Receptor-Mediated Signal Transduction in Xenopus Oocytes Expressing the Rat M1 Receptor
- Two distinct inactivation processes related to phosphorylation in cardiac L-type Ca^ channel currents
- Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^ Influx in Cultured Bovine Adrenal Chromaffin Cells
- Increases in Serum Nitrite and Nitrate of a New-Fold Adversely Affect the Outcome of Pregnancy in Rats
- Structural Study of Silk-like Peptides Modified by the Addition of the Cell Adhesive Sequence, RGD, Using ^C CP/MAS NMR
- Pulsed NMR Study of the Curing Process of Epoxy Resin
- Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach
- Facilitation of Acetylcholine Release by SK-951, a Benzofuran Derivative, via the 5-Hydroxytryptamine_4 Receptor in Guinea Pig Stomach
- Identification of SK-951, a Novel Benzofuran Derivative, as an Agonist to 5-HT_4 Receptors
- Immunohistochemical approach for differential expression of protein kinase C subspecies
- Immunohistochemical Localization of Cyclic Nucleotides in the Rat Articular Cartilage and Synovial Membrane
- INHIBITORY EFFECT OF (+)THREO-3, 4-DIHYDROXY-PHENYLSERINE (DOPS) ON DECARBOXYLATION OF (-)THREO-DOPS
- NEONATAL AND SENESCENT CHANGES IN L-AROMATIC AMINO ACID DECARBOXYLASE AND MONOAMINE OXIDASE ACTIVITIES IN KIDNEY, LIVER, BRAIN AND HEART OF THE RAT
- 6. Effect of Amantadine on Serotonin Metabolism in Rat Brain
- Immunohistochemical Localization of GABA and Aspartate in the Rat Pancreas
- Characterization and Purification of Aspartate Antiserum and its application to Immunohistochemistry
- Immunohistochemistry of GABA and aspartate in the vestibular nuclei of the guinea pig
- Fluorescence Histochemical Demonstration of Adrenergic Nerve Fibers in the Hip Joint Capsule
- Activation of a Potassium Conductance by Extracellular Alkaline pH in Oocytes of Xenopus laevis
- 5-Hydroxytryptamine Receptors, Especially the 5-HT_4 Receptor, in Guinea Pig Urinary Bladder
- MODIFICATION OF THE TONUS AND DRUG-INDUCED CONTRACTION OF THE ISOLATED RAT ILEUM BY REMOVAL OF Na FROM BATHING MEDIA
- INFLUENCES OF AMINOPHYLLINE AND REDUCTION IN EXTERNAL Na ON THE ANTISPASMODIC ACTION OF ISOPROTERENOL IN THE ISOLATED RAT RECTUM
- The Locus Coeruleus of the Rhesus Monkey;Noradrenergic Cell Distribution and its Ascending Projection
- Inhibitory effects of monoamine oxidase inhibitors on the growth of pea and rice seedlings
- Electron-Phonon Interaction Mechanism of Temperature Induced Ferromagnetism : II. LOW TEMPERATURE PROPERTIES OF SOLIDS : Magnetism : Rare Earth etc.
- Photoaffinity labeling of the D_1 dopamine receptor : I. Biochemical basis of microautoradiography
- Photoaffinity labeling of the D_1 dopamine receptor : II. Application to microautoradiography
- HISTOCHEMICAL STUDY OF THE CENTRAL MONOAMINE NEURON SYSTEMS IN THE TORTICOLLIS OF CAT (SYMPOSIUM ON HISTOCHEMISTRY AND CYTOCHEMISTRY OF NEUROTRANSMITTERS AND ITS CLINICAL APPLICATION)
- Plasma Nucleosome Levels in Node-Negative Breast Cancer Patients
- LEVELS OF TYROSINE AND TRYPTOPHAN IN THE PLASMA AND BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS
- Immunocytochemical Localization of cyclic AMP and cyclic GMP in Synchronously Dividing Tetrahymena
- ENZYMATIC DECARBOXYLATION OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE IN RAT HEART
- DOPAMINE ACCUMULATION IN THE MOUSE BRAIN UNDER HYPOXIA
- THIAMINE ACCUMULATION INDUCED BY L-5-HYDROXY-TRYPTOPHAN IN RAT BRAIN
- Mechanism of Inhibitory Actions of Geranium thunbergii, Tannic Acid and Geraniin on the Motility of Rat Intestine
- Microspectrofluorometric Identification and Quantitative Histochemistry of Biogenic Amines (Histochemistry of Bioactive Amines)
- Increases in Serum Nitrite and Nitrate of a Few-Fold Adversely Affect the Outcome of Pregnancy in Rats
- SKELETAL CHANGES INDUCED BY DOPA DECARBOXYLASE INHIBITOR IN RATS
- Evidence for the presence of D2 and 5-HT2 receptors in the human prefrontal cortex.
- Ascending norepinephrine pathways impaired in experimental hydrocephalus.
- Cyclic adenosine 3',5'-monophosphate levels in response to norepinephrine in rectum of postnatal rats.
- Effects of MPC-1304, a Novel Calcium Antagonist, on Stroke-Prone Spontaneously Hypertensive Rats
- GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
- Novel type of monoclonal antibodies against cyclic GMP and application to immunocytochemistry of the rat brain.
- Expression of the Endothelin Receptors in the Hippocampus of SHRSP after Transient Forebrain Ischemia
- Role of protein kinase C in the vesicular release of acetylcholine and norepinephrine from enteric neurons of the guinea pig small intestine.
- Specific Binding Sites for Endothelins in the Central Nervous System
- Antimuscarinic effects of antihistamines : Quantitative evaluation by receptor-binding assay.
- (3H)GBR-12935 binding sites in human striatal membranes: Binding characteristics and changes in Parkinsonians and schizophrenics.
- Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices.