Gain of 11q by an Additional Ring Chromosome 11 and Trisomy 18 in CD5-Positive Intravascular Large B-Cell Lymphoma
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概要
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Chromosomal abnormalities of intravascular large B-cell lymphoma (IVLBCL), a rare form of extranodal diffuse large Bcell lymphoma, have been described in only a small number of cases. A 59-year-old female presented with pancytopenia and splenomegaly. Bone marrow was normocellular with 30.4% abnormal large lymphoid cells that were positive for CD5, CD19, CD20, HLA-DR and λ chain. Bone marrow biopsy showed intrasinusoidal infiltration of large lymphoid cells. G-banding and spectral karyotyping of the bone marrow cells demonstrated a complex karyotype as follows : 48,XX,-8,+r(11),+12,del(12)(p?) ×2,+18,der(19)(19?::p13→qter),der(21)t(8;21)(q11.2;p11.2). Fluorescence <I>in situ</I> hybridization on interphase nuclei revealed three signals of <I>CCND1</I> at 11q13, but two signals of <I>BIRC3</I> at 11q22 and <I>MLL</I> at 11q23, indicating that r(11) contained <I>CCND1</I>. Together with other reported cases, our results indicate that the gain of 11q as well as trisomy 18 may be among the recurrent chromosomal aberrations in IVLBCL. Furthermore, an additional ring chromosome 11 could be a novel mechanism leading to the gain of 11q. [<I>J Clin Exp Hematop 53(2) : 161-165, 2013</I>]
著者
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HAYASHI Yoshitake
Division of Molecular Medicine & Medical Genetics, International Center for Medical Research and Tre
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Okamura Atsuo
Division Of Hematology Department Of Medicine Kobe University Graduate School Of Medicine
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Yamamoto Katsuya
Division Of Hematology Department Of Medicine Kobe University Graduate School Of Medicine
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Yakushijin Kimikazu
Division Of Medical Oncology/hematology Department Of Medicine Kobe University Graduate School Of Me
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Matsuoka Hiroshi
Division Of Medical Oncology/hematology Department Of Medicine Kobe University Graduate School Of Me
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Minami Hironobu
Division Of Medical Oncology/hematology Department Of Medicine Kobe University Graduate School Of Me
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HAYASHI Yoshitake
Division of Molecular Medicine and Medical Genetics, Department of Pathology, Kobe University Graduate School of Medicine
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Okamura Atsuo
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine
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Yakushijin Kimikazu
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine
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MATSUOKA Hiroshi
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine
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Yamamoto Katsuya
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine
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