WHHL家兎冠血管におけるprostacyclinの反応性と生成能 : two stageでの検討

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In order to investigate the effects of prostacyclin (PGI_2) and arachidonic acid (AA) on the response in atherosclerotic coronary vessel wall, the present studies were carried out. Six WHHL- rabbits, three in 3 months old and three in 7 months old, and eleven normal rabbits, five in 3 months old and six in 7 months old, were used for this experiment. The influence of PGI_2 and AA on the coronary flow in WHHL-rabbit heart and normal rabbit heart were observed by the Langendorff's method under the constant perfusion pressure. At the end of experiment, the coronary arteries were histologically examined. The results were as follows : 1) Serum cholesterol and triglyceride levels in WHHL-rabbits were significantly higher than those in normal rabbits, but serum HDL-cholesterol levels were 'not different from those in normal rabbits. 2) Based on the histological appearance in coronary arteries of WHHL-rabbits, atherosclerotic changes were found in one of 3 months old and all of 7 months old, while in those of normal rabbits were not found. 3) The respose of coronary arteries to PGI_2 was estimated by the % change of the coronary flow (△CF) after the infusion of PGI_2 into the coronary arteries. There were no differences in △CF between WHHL-rabbits and normal rabbits. 4) The synthetic capacity of PGI_2 in coronary arteries from exogenous AA was estimated by the ratio of △CF by AA to △CF by PGI_2. This ratio was slightly decreased in 3 months old WHHL-rabbits and significantly decreased in 7 months old WHHL-rabbits as compared to agematched normal rabbits. From these results, it is suggested that PGI2 synthetic capacity in atherosclerotic coronary arteries is decreased, compared with age-matched normal coronary arteries.
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