Synthetic Studies on Dolabellane Diterpenoids. Synthesis of 10-epi-Clavudiol A, an Epimer of a Marine Dolabellanoid
スポンサーリンク
概要
- 論文の詳細を見る
In the line of our synthetic studies on the medium-ring containing higher terpenoids, we have applied our strategy, which is featured by obtaining a diterpenic skeleton from two monoterpene units, to the synthesis of the dolabellane family having a fused 5-11 bicyclic skeleton. From functionalized iridoid and geranyl synthons, 10-epi-clavudiol A, an epimer of marine dolabellane clavudiol A, has been totally synthesized. Noteworthy steps include a feasible isomerization of the more substituted double bond to the less substituted one via the reduction of the allylic chloride mediated by Cr(II)Cl_2 in the presence of alcoholic proton source and an intramolecular pinacol coupling to form the eleven-membered ring.
- 九州大学の論文
- 1998-07-31
著者
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加藤 修雄
大阪大学産業科学研究所
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TAKESHITA Hitoshi
Tohwa Institute for Orient Studies, Tohwa Unviersity
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Takeshita H
Kyushu Univ.
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Takeshita Hitoshi
Tohwa University
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Takeshita Hitoshi
Tohwa Institute For Orient Studies Tohwa University
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Kato N
Osaka Univ. Ibaraki Jpn
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Kato N
Department Of Bacteriology Nagoya University School Of Medicine
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Omoto Mineko
Interdisciplinary Graduate School of Engineering Sciences Kyushu University
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加藤 修雄
阪大産研
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Mori A
Department Of Synthetic Chemistry The University Of Tokyo
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